New disguises for an old channel:: MaxiK channel β-subunits
New disguises for an old channel:: MaxiK channel β-subunits
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DOI：
10.1152/nips.01387.2002
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发表时间：
2002-08-01
期刊：
影响因子：
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通讯作者：
Latorre, R
中科院分区：
文献类型：
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作者：
Orio, P;Rojas, P;Latorre, R
Ca2+ 激活的大电导 K+ 通道（MaxiK 或 BK 通道）控制多种生理过程，包括平滑肌张力、神经分泌和听力。尽管由单个基因（Slowpoke）编码，MaxiK 通道的多样性却很大。调节性β亚基、剪接和代谢调节创造了这种多样性，这对于许多组织的充分功能至关重要。
Ca2+-activated K+ channels of large conductance (MaxiK or BK channels) control a large variety of physiological processes, including smooth muscle tone, neurosecretion, and hearing. Despite being coded by a single gene (Slowpoke), the diversity of MaxiK channels is great. Regulatory beta-subunits, splicing, and metabolic regulation create this diversity fundamental to the adequate function of many tissues.