Overrepresentation of Mood and Anxiety Disorders in Adults With Autism and Their First-Degree Relatives: What Does it Mean?
Overrepresentation of Mood and Anxiety Disorders in Adults With Autism and Their First-Degree Relatives: What Does it Mean?
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DOI：
10.1002/aur.23
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发表时间：
2008-06-01
期刊：
影响因子：
4.7
通讯作者：
Lainhart, Janet E.
中科院分区：
文献类型：
--
作者：
Mazefsky, Carla A.;Folstein, Susan E.;Lainhart, Janet E.
研究表明，自闭症患者的亲属患情感障碍的比率高于普通人群以及其他发育障碍儿童的家庭。此外，自闭症患者并发情绪和焦虑障碍的比率较高。本研究试图通过记录先证者（自闭症患者）及其家庭成员中情感障碍的存在情况，找出先前这些发现的可能原因。来自巴尔的摩自闭症家庭研究的17名成年自闭症患者及其一级亲属的子样本完成了一次结构化的精神病学访谈。结果显示，先证者患情绪障碍和焦虑障碍的比率分别为35%和77%，且这些障碍在至少一名一级亲属中的出现比率分别为71%和29%。对家庭内部模式的探究表明，母亲有情绪障碍病史的先证者中，80%自身也患有情绪障碍，而母亲没有情绪障碍病史的先证者中，只有16%自身患有情绪障碍。鉴于样本量较小，这些结果必须被视为初步的。在更大的样本中重复这些发现将有助于阐明是否确实存在情绪障碍风险增加的情况，这对预防工作以及理解可能的遗传机制具有潜在影响。
Research indicates that relatives of individuals with autism have higher rates of affective disorders than both the general population and families of children with other developmental disabilities. In addition, individuals with autism have high rates of co-morbid mood and anxiety disorders. This study sought to identify possible reasons for these previous findings by documenting the presence of affective disorders in both probands (the individuals with autism) and their family members. A sub-sample of 17 adults with autism and their first-degree relatives from the Baltimore Family Study of Autism completed a structured psychiatric interview. The results indicated that the rates of mood and anxiety disorders were 35 and 77%, respectively, for probands, and these disorders were present in at least one first-degree relative at rates of 71 and 29%, respectively. Exploring patterns within families revealed that 80% of probands with a mother who had a mood disorder history also had a mood disorder themselves, compared to only 16% of probands whose mothers did not have a mood disorder history. The results must be considered preliminary given the small sample size. Replicating these findings in a larger sample would help clarify whether a true increased risk of mood disorder exists, which would have potential implications for prevention efforts and understanding possible genetic mechanisms.