Monocytes are progressively activated in the circulation of pregnant women
Monocytes are progressively activated in the circulation of pregnant women
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DOI：
10.1189/jlb.72.5.874
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发表时间：
2002-11
影响因子：
5.5
通讯作者：
P. Luppi;C. Haluszczak;Dawn M Betters;C. A. Richard;M. Trucco;J. Deloia
中科院分区：
文献类型：
--
作者：
P. Luppi;C. Haluszczak;Dawn M Betters;C. A. Richard;M. Trucco;J. Deloia
妊娠的特征是存在全身性白细胞活化。我们用流式细胞仪研究了妊娠期孕妇循环中粒细胞、单核细胞和T淋巴细胞表型和细胞内细胞因子的变化。我们报告说，外周循环的特点是增加的粒细胞和淋巴细胞的百分比减少。单核细胞的比例在整个妊娠期间保持稳定;然而，检测到表面标志物CD 11 a、CD 54和CD 64的进行性上调。与非妊娠状态相比，单核细胞也显示出更高的白细胞介素（IL）-12和IL-1β的产生，粒细胞合成IL-8的潜力更大。所有这些变化在妊娠后期尤为明显。T淋巴细胞没有任何活化状态的特征，并显示出IL-6产生减少。这些发现表明，母体单核细胞和粒细胞的激活在妊娠期间增加，并支持妊娠导致先天免疫系统升高和适应性免疫系统抑制的观点。
Pregnancy is characterized by the presence of generalized leukocyte activation. We used flow cytometry to investigate changes in phenotype and intracellular cytokines of circulating granulocytes, monocytes, and T lymphocytes of pregnant women during gestation. We report that peripheral circulation of pregnancy is characterized by an increased percentage of granulocytes and a decrease in lymphocytes. The proportion of monocytes remains stable throughout gestation; however, a progressive up‐regulation of surface markers CD11a, CD54, and CD64 was detected. Monocytes also showed higher production of interleukin (IL)‐12 and IL‐1β compared with the nonpregnant state, and granulocytes had greater potential to synthesize IL‐8. All these changes were particularly marked in late gestation. T lymphocytes did not have any characteristics of the activated state and showed a decreased IL‐6 production. These findings demonstrate that activation of maternal monocytes and granulocytes increases during pregnancy and support the idea that pregnancy results in an elevation of the innate immune system and suppression of the adaptive immune system.