CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system
CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system
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DOI：
10.1089/vim.2007.0056
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发表时间：
2007-12-01
期刊：
影响因子：
2.2
通讯作者：
Lane, Thomas E.
中科院分区：
文献类型：
--
作者：
Hickey, Michelle J.;Held, Katherine S.;Lane, Thomas E.
在病毒诱导的神经系统疾病模型中确定了CC趋化因子受体1 （CCR1）在宿主防御和疾病发展中的作用。小鼠肝炎病毒（MHV）脑内（IC）感染导致急性脑炎，随后出现与多发性硬化症（MS）病理相似的慢性脱髓鞘疾病。与野生型（CCR1(+/+)）小鼠相比，缺乏CCR1的小鼠（CCR1(-/-)）感染MHV后的急性期死亡率未观察到增加。然而，在感染后21 d， 74%的CCR1（-/-）小鼠死亡，而CCR1（+/+）小鼠的死亡率仅为32%，这表明通过CCR1的趋化因子信号传导显著(p
The role of CC chemokine receptor 1 (CCR1) in host defense and disease development was determined in a model of viral-induced neurologic disease. Intracerebral (IC) infection of mice with mouse hepatitis virus (MHV) results in an acute encephalitis followed by a chronic demyelinating disease similar in pathology to the disease multiple sclerosis (MS). No increase in mortality was observed during the acute phase of disease following MHV infection of mice lacking CCR1 (CCR1(-/-)) as compared to wild-type (CCR1(+/+)) mice. However, by 21 d post-infection, 74% of CCR1(-/-) mice had succumbed to death compared to only 32% mortality of CCR1(+/+) mice, indicating that chemokine signaling through CCRl significantly (p