An organocatalytic asymmetric double Michael cascade reaction of unsaturated ketones and unsaturated pyrazolones: highly efficient synthesis of spiropyrazolone derivatives.
An organocatalytic asymmetric double Michael cascade reaction of unsaturated ketones and unsaturated pyrazolones: highly efficient synthesis of spiropyrazolone derivatives.
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DOI：
10.1039/c2ob27095a
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发表时间：
2013-02
影响因子：
3.2
通讯作者：
Jinyan Liang;Qiao Chen;Luping Liu;Xianxing Jiang;Rui Wang
中科院分区：
文献类型：
--
作者：
Jinyan Liang;Qiao Chen;Luping Liu;Xianxing Jiang;Rui Wang
The first organocatalytic double Michael cascade reaction between unsaturated ketones and unsaturated pyrazolones has been developed which provides spiropyrazolone core structures containing two interval or three consecutive stereogenic centers with excellent diastereo- (>20:1) and enantioselectivities (up to 99% ee). Moreover, a pair of enantiomers and can be achieved via different catalysts.
