Cell biology of Zymoseptoria tritici: Pathogen cell organization and wheat infection.
Cell biology of Zymoseptoria tritici: Pathogen cell organization and wheat infection.
复制标题
DOI：
10.1016/j.fgb.2015.04.002
复制
发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Steinberg G
中科院分区：
文献类型：
--
作者：
Steinberg G
感染的细胞生物学开始阐明宿主-病原体相互作用。这种真菌病原体的细胞生物学研究还很不充分。加强细胞生物学研究有望找到新的杀真菌剂靶点，并将有助于作用模式研究。小麦病原菌Zymoseptoria triuminicola（以前称为禾生球腔菌）的细胞生物学研究已经导致对感染过程的组织学有了很好的理解。表达谱分析和生物信息学方法，结合信号通路，效应器和潜在的坏死因子的分子研究，提供了第一个洞察宿主和病原体之间的复杂相互作用。细胞生物学研究将有助于我们进一步了解该真菌的感染策略。真菌本身的细胞组织和细胞内动力学在很大程度上未被探索。深入了解病原体内的基本细胞过程将扩大我们对Z的基础生物学的知识。三唑盐，从而提供推定的新的抗真菌靶标。
Cell biology of the infection begins to shed light on the host–pathogen interaction. The cell biology of the fungal pathogen is highly understudied. Intensified cell biology research promises new fungicide targets and will help mode-of-action studies. Cell biological research in the wheat pathogen Zymoseptoria tritici (formerly Mycosphaerella graminicola) has led to a good understanding of the histology of the infection process. Expression profiling and bioinformatic approaches, combined with molecular studies on signaling pathways, effectors and potential necrosis factors provides first insight into the complex interplay between the host and the pathogen. Cell biological studies will help to further our understanding of the infection strategy of the fungus. The cellular organization and intracellular dynamics of the fungus itself is largely unexplored. Insight into essential cellular processes within the pathogen will expand our knowledge of the basic biology of Z. tritici, thereby providing putative new anti-fungal targets.