Detecting traumatic brain injury-induced coagulopathy: What we are testing and what we are not.
Detecting traumatic brain injury-induced coagulopathy: What we are testing and what we are not.
复制标题
检测创伤性脑损伤引起的凝血病：我们正在测试什么，没有测试什么。
DOI：
10.1097/ta.0000000000003748
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zhang,Jianning
中科院分区：
文献类型：
--
作者：
Dong,Jing-Fei;Zhang,Fangyi;Zhang,Jianning
Coagulopathy after traumatic brain injury (TBI) is common and has been closely associated with poor clinical outcomes for the affected patients.Traumatic brain injury-induced coagulopathy (TBI-IC) is consumptive in nature and evolves rapidly from an injury-induced hypercoagulable state. Traumatic brain injury-induced coagulopathy defined by laboratory tests is significantly more frequent than clinical coagulopathy, which often manifests as secondary, recurrent, or delayed intracranial or intracerebral hemorrhage. This disparity between laboratory and clinical coagulopathies has hindered progress in understanding the pathogenesis of TBI-IC and developing more accurate and predictive tests for this severe TBI complication. In this review, we discuss laboratory tests used in clinical and research studies to define TBI-IC, with specific emphasis on what the tests detect and what they do not. We also offer perspective on developing more accurate and predictive tests for this severe TBI complication.(J Trauma Acute Care Surg. 2023; 94: S50-S55. Copyright© 2022 Wolters Kluwer Health, Inc. All rights reserved.)
