An In Vivo Comparison of Commonly Used Topical Antimicrobials on Skin Graft Healing After Full-Thickness Burn Injury
An In Vivo Comparison of Commonly Used Topical Antimicrobials on Skin Graft Healing After Full-Thickness Burn Injury
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DOI：
10.1097/bcr.0000000000000072
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发表时间：
2015-03-01
影响因子：
1.4
通讯作者：
Haberal, Mehmet
中科院分区：
文献类型：
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作者：
Abbas, Ozan L.;Borman, Huseyin;Haberal, Mehmet
局部抗菌药物常用于烧伤患者的局部感染控制。据推测，这些药物会延迟伤口愈合。关于局部抗菌药物对皮肤移植愈合的影响的数据有限。在这项研究中，我们的目的是评估的影响，呋喃西林，1%银磺胺嘧啶，聚维酮碘对皮肤移植愈合。本研究中使用了40只雄性大鼠。将网状皮肤移植物放置在切除的烧伤伤口上，用作模型以比较局部药剂与对照组。分析了皮肤移植物存活率、网状移植物间隙闭合（基于物理参数，即上皮化和伤口收缩）和组织学变化。各组移植物成活率均超过85%。各组移植物存活率的平均值之间没有差异（P > 0.05）。呋喃西林组动物上皮化发生明显提前（P <0.05）。两组的伤口收缩率无显著差异（P > 0.05）。移植皮片活检标本之间无组织学差异。在从网状移植物间隙中获得的样本中，未发现组间关于伤口愈合参数的显著差异（P > 0.05）。我们发现，在非污染的烧伤创面中，呋喃西林、磺胺嘧啶银和聚维酮碘对移植物愈合和吸收没有负面影响。
Topical antimicrobials are frequently used for local control of infections in burn patients. It has been postulated that these agents retard wound healing. There are limited data about the effects of topical antimicrobial agents on skin graft healing. In this study, we aimed to evaluate the effects of nitrofurazone, 1% silver sulfadiazine, and povidone-iodine on skin graft healing. Forty male rats were used in this study. A meshed skin graft, placed on an excised burn wound, was used as a model to compare topical agents with a control group. Skin graft survival rates, closure of meshed graft interstices (based on physical parameters, namely epithelialization and wound contraction), and histological changes were analyzed. Graft take was more than 85% in all groups. There was no difference between the mean values of the percent graft survival for each group (P > .05). Epithelialization occurred significantly earlier in animals in the nitrofurazone group (P < .05). There was no significant difference between groups in wound contraction rates (P >.05). There was no histological difference between the biopsy specimens of skin grafts. In specimens obtained from the interstices of the meshed graft, no significant differences were found among the groups regarding the wound healing parameters (P > .05). We found that nitrofurazone, silver sulfadiazine, and povidone-iodine had no negative effect on graft healing and take in noncontaminated burn wounds.