Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults
Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults
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DOI：
10.1093/cid/ciab549
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发表时间：
2021-07-25
影响因子：
11.8
通讯作者：
Wilcox, Mark H.
中科院分区：
文献类型：
--
作者：
Johnson, Stuart;Lavergne, Valery;Wilcox, Mark H.
本临床实践指南是对成人艰难梭菌感染（CDI）管理的重点更新，特别是针对非达索霉素和bezlotoxumab治疗CDI的使用。本指南由代表美国传染病学会（IDSA）和美国卫生保健流行病学学会（SHEA）的多学科小组制定。本指南适用于照顾成人CDI的医疗保健专业人员，包括传染病专家、胃肠病学家、医院医生、药剂师以及照顾这些患者的任何临床医生和医疗保健提供者。该小组对管理CDI的建议是基于从特定主题的系统文献综述中得出的证据。以下是成人CDI治疗的建议。专家组遵循了一个系统的过程，其中包括使用GRADE方法对证据的确定性和建议的强度进行评级的标准化方法（建议评估、发展和评估的分级）。全文可在网上找到支持每项建议的背景、方法、证据总结和基本原理的详细描述，以及知识差距。
This clinical practice guideline is a focused update on management of Clostridioides difficile infection (CDI) in adults specifically addressing the use of fidaxomicin and bezlotoxumab for the treatment of CDI. This guideline was developed by a multidisciplinary panel representing the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). This guideline is intended for use by healthcare professionals who care for adults with CDI, including specialists in infectious diseases, gastroenterologists, hospitalists, pharmacists, and any clinicians and healthcare providers caring for these patients. The panel's recommendations for the management CDI are based upon evidence derived from topic-specific systematic literature reviews. Summarized below are the recommendations for the management of CDI in adults. The panel followed a systematic process which included a standardized methodology for rating the certainty of the evidence and strength of recommendation using the GRADE approach (Grading of Recommendations Assessment, Development, and Evaluation). A detailed description of background, methods, evidence summary and rationale that support each recommendation, and knowledge gaps can be found online in the full text.