An overview on the homeostasis of Ca2+ in chemoreceptor cells of the rabbit and rat carotid bodies
An overview on the homeostasis of Ca2+ in chemoreceptor cells of the rabbit and rat carotid bodies
复制标题
DOI：
10.1007/0-387-31311-7_33
复制
发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Gonzalez, C
中科院分区：
文献类型：
--
作者：
Conde, SV;Caceres, AI;Gonzalez, C
颈动脉体 (CB) 化学感受器感知动脉 PO2 和 PCO2/pH 在缺氧缺氧和所有类型的酸中毒中被激活。 CB 中的传感结构是化学感受器细胞 (CBCC)，它们与颈动脉窦神经 (CSN) 的感觉神经末梢有突触连接。在缺氧和酸中毒的情况下，CBCC 被激活，神经递质 (NT) 的释放速率增加，促进 CSN 活性增加以及随后的通气和心血管反射 (5)。自然刺激诱导的 NT 释放取决于细胞外环境中 Ca2+ 的存在 (4, 10)。 Ca2+ 通过电压驱动的 Ca2+ 通道 (VOCC; 10, 11) 进入细胞并触发 NT 的胞吐释放。然而，CBCC 在刺激期间的 Ca2+ 稳态以及刺激后基础 Ca2+ 水平的恢复的几个方面尚未被研究。
Carotid body (CB) chemoreceptors sense arterial PO2 and PCO2/pH becoming activated in hypoxic hypoxia and in all types of acidosis. The sensing structures in the CB are chemoreceptor cells (CBCC), which are connected synaptically with the sensory nerve endings of the carotid sinus nerve (CSN). In situations of hypoxia and acidosis, CBCC are activated and their rate of release of neurotransmitters (NT) increase, promoting an increase in the activity of the CSN and subsequent ventilatory and cardiovascular reflexes (5). The release of NT induced by natural stimuli is dependent on the presence of Ca2+ in the extracellular milieu (4, 10). Ca2+ enters the cells via voltage operated-Ca2+ channels (VOCC; 10, 11) and triggers the exocytotic release of NT. However, there are several aspects of the homeostasis of Ca2+ by CBCC during stimulation and the recovery of basal Ca2+ levels in the post stimulus period that have nor been studied.