Chance caught on the wing:: cis-regulatory evolution and the origin of pigment patterns in Drosophila
Chance caught on the wing:: cis-regulatory evolution and the origin of pigment patterns in Drosophila
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DOI：
10.1038/nature03235
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发表时间：
2005-02-03
期刊：
影响因子：
64.8
通讯作者：
Carroll, SB
中科院分区：
文献类型：
--
作者：
Gompel, N;Prud'homme, B;Carroll, SB
形态性状的获得、丢失或修改通常与发育过程中基因调控的变化有关。然而，这些进化变化背后的分子基础仍然难以捉摸。在这里，我们确定了在果蝇双足动物中雄性特有的翅膀色素斑点进化获得的分子机制之一，果蝇双足动物是与黑腹果蝇密切相关的物种。我们表明，这个斑点的进化涉及到黄色色素沉着基因的祖先顺式调节元件的修改。该元件获得了转录因子的多个结合位点，这些转录因子是控制翅膀发育的调控景观中高度保守的组成部分，包括选择器蛋白Engraated。调控景观成分的进化稳定性可以通过顺式调控元件的偶然突变来补充，这可能解释了类似形态模式的重复进化，例如苍蝇的翅膀色素模式。
The gain, loss or modification of morphological traits is generally associated with changes in gene regulation during development. However, the molecular bases underlying these evolutionary changes have remained elusive. Here we identify one of the molecular mechanisms that contributes to the evolutionary gain of a male-specific wing pigmentation spot in Drosophila biarmipes, a species closely related to Drosophila melanogaster. We show that the evolution of this spot involved modifications of an ancestral cis-regulatory element of the yellow pigmentation gene. This element has gained multiple binding sites for transcription factors that are deeply conserved components of the regulatory landscape controlling wing development, including the selector protein Engrailed. The evolutionary stability of components of regulatory landscapes, which can be co-opted by chance mutations in cis-regulatory elements, might explain the repeated evolution of similar morphological patterns, such as wing pigmentation patterns in flies.