Allogeneic Stem Cell Transplantation with CD34+ Cell Selection.
Allogeneic Stem Cell Transplantation with CD34+ Cell Selection.
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DOI：
10.2991/chi.d.190613.001
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发表时间：
2019-09
影响因子：
--
通讯作者：
Barba P
中科院分区：
文献类型：
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作者：
Roldan E;Perales MA;Barba P
急性和慢性移植物抗宿主病(GvHD)的发展直接影响治疗相关的死亡率和发病率，阻碍了异基因干细胞移植的成功。因此，通过阳性选择CD34+细胞去除T细胞已成为减少这些患者急、慢性移植物抗宿主病的一种有前景的策略。本文综述了CD34+细胞选择的异基因干细胞移植的主要特点，包括移植物失败、移植物抗宿主病、感染、器官毒性和长期存活的风险。此外，我们强调了未来的战略，以改善该平台的结果，并巩固其在临床实践中的使用。
The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft-versus-host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.