Peripheral administration of low pH solutions causes activation and sensitisation of convergent dorsal horn neurones in the anaesthetised rat
Peripheral administration of low pH solutions causes activation and sensitisation of convergent dorsal horn neurones in the anaesthetised rat
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DOI：
10.1016/s0304-3940(00)01759-6
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发表时间：
2001-02-09
影响因子：
2.5
通讯作者：
Dickenson, AH
中科院分区：
文献类型：
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作者：
Carpenter, KJ;Nandi, M;Dickenson, AH
这是第一次在体内研究外周给予酸对脊髓背角神经元活动的影响。会聚神经元的细胞外记录显示，通过向外周感受野施用低pH溶液引起的神经元活动增加。活性阈值范围为pH 5.85至2.5。响应的幅度随着pH值的降低而增加;在pH 2.5时达到最大效应（648 +/-181个动作电位/60 s，而对照诱发的活动为86.3 +/-29个动作电位/60 s）。活动持续长达60秒，可能代表溶液能够超过完整后爪的缓冲能力的时间。还观察到神经元对无害（von Frey细丝9 g）和有害（30 g）机械点状刺激的显着敏感化。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
This is the first study to exam the the effects of peripheral administration of acid on the activity of dorsal horn neurones in vivo. Extracellular recordings from convergent neurones revealed increases in neuronal activity evoked by administration of low pH solutions into the peripheral receptive field. Threshold for activity ranged from pH 5.85 to 2.5. The magnitude of responses increased with decreasing pH; maximum effects were achieved with pH 2.5 (648 +/- 181 action potentials/60 s, as compared to control-evoked activity of 86.3 +/- 29 action potentials/60 s). Activity lasted for up to 60 s, likely to represent the time for which the solutions were able to surmount the buffering capacity of the intact hindpaw. Significant sensitisation of the neurones to both innocuous (von Frey filament 9 g) and noxious (30 g) mechanical punctate stimuli was also observed. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.