Interactions between Biomaterials and Biological Tissues and Cells, Part I
Interactions between Biomaterials and Biological Tissues and Cells, Part I
复制标题
生物材料与生物组织和细胞之间的相互作用，第一部分
DOI：
10.1007/s11837-022-05420-y
复制
发表时间：
2022
期刊：
影响因子：
2.6
通讯作者：
Thomas, Vinoy
中科院分区：
文献类型：
--
作者：
Du, Jing;Katti, Dinesh;Thomas, Vinoy
生物材料是设计用于模拟或替代生物材料的材料。工程生物材料和生物系统之间的相互作用是材料科学和工程中一个快速发展的跨学科前沿，具有无限的应用。相互作用可以是物理的、机械的、生物的或生物化学的。在这些过程中，重要的问题包括但不限于生物界面、机械生物学、生物相容性、组织相容性、炎症反应、生物降解、毒性、组织再生、蛋白质-材料相互作用和细胞-材料相互作用。本专题收集了与各种生物材料和生物组织、细胞和分子之间的相互作用有关的评论和原始研究论文。工程生物材料包括金属、聚合物、生物陶瓷及其复合材料。研究了与骨、韧带、成纤维细胞、间充质干细胞和微生物细胞的相互作用。研究结果为生物学、医学、生物工程、食品工业和生物制造，特别是人造肉提供了光明。在损伤韧带和肌腱的修复中，移植物的固定是至关重要的，因为移植物和骨之间的附着点对肌肉骨骼运动至关重要。在一篇原始研究论文中，Dean等人使用喷墨打印在高度对齐和化学改性的聚乳酸（PLA）支架表面上创建纳米颗粒羟基磷灰石的梯度图案。在固定纤维蛋白后，他们在体外证明了人类间充质干细胞（hMSC）在样品表面的增殖和分化反应。在另一篇原创研究论文中，Bose和她的团队研究了大蒜素（一种来自大蒜的分子）对骨骼健康的影响，方法是制造一种新型的载大蒜素的羟基磷灰石药物递送系统。对S.金黄色葡萄球菌，大蒜素释放动力学，并与成骨细胞的细胞相容性进行了研究。结果表明，大蒜素支架作为骨组织工程的定位载体具有潜在的应用前景。Li等人介绍了两种植入物结构的生物力学性能的实验表征结果，用于第一跗跖骨的重新对准和关节固定，以解决拇外翻（一种前足畸形）。在他们的尸体模型中，两种结构都保持了第一跗跖关节间隙的压缩和残余稳定性。与镍钛合金斯台普斯相比，其在加载过程中的性能具有统计学上的上级优势。植入物相关感染和抗生素耐药性是生物医学材料在体内成功的挑战。在一项原始研究中，Roy等人强调了探索具有良好杀菌效率的纳米形貌的必要性。钛的干蚀刻结晶织构对革兰氏阳性菌和革兰氏阴性菌均有杀菌作用。
Biomaterials are those materials that are designed to mimic or replace biological materials. The interactions between engineered biomaterials and biological systems is a rapidly growing, interdisciplinary frontier in materials science and engineering with endless applications. The interactions can be physical, mechanical, biological, or biochemical. In these processes, the important issues include, but are not limited to, biointerfaces, mechanobiology, biocompatibility, tissue compatibility, inflammatory responses, biodegradation, toxicity, tissue regeneration, protein–materials interactions, and cell–material interactions. This special topic presents a collection of reviews and original research papers related to the interactions between various biomaterials and biological tissues, cells, and molecules. The engineered biomaterials include metals, polymers, bioceramics, and their composites. The interactions with bone, ligament, fibroblasts, mesenchymal stem cells, and microbial cells are studied. The results shed light on biology, medicine, bioengineering, the food industry, and biomanufacturing, especially in artificial meat. In the repair of injured ligaments and tendons, the fixation of grafts is crucial, because enthesis between graft and bone is essential for musculoskeletal motion. In an original research paper, Dean et al. used inkjet-printing to create a graded pattern of nanoparticulate hydroxyapatite on the surface of highly-aligned and chemically modified poly (lactic acid)(PLA) nanofiber scaffolds. Following immobilization of fibrin, they then demonstrated the proliferation and differentiation response of human mesenchymal stem cells (hMSC) in vitro on the surface of the samples. In another original research paper, Bose and her team studied the effects of allicin, a molecule from garlic, on bone health by the fabrication of a novel allicin-loaded hydroxyapatite drug delivery system. The antibacterial efficiency against S. aureus, the allicin release kinetics, and the cytocompatibility with osteoblasts were investigated. The results indicated potential applications for the allicinloaded scaffolds to be a localized delivery vehicle for bone tissue engineering. Li et al. presented the results of experimental characterization of the biomechanical performance of two implant constructs for the realignment and arthrodesis of the first tarsometatarsal to address hallux valgus, a forefoot deformity. In their cadaver model, both constructs maintained compression and residual stability of the first tarsometatarsal joint gap. They provided statistically superior performance during loading compared to nitinol staples. Implant-associated infection and antibiotic resistance is a challenge in biomedical materials’ success in vivo. In an original research study, Roy et al. emphasized the need for exploring nanotopographies with good bactericidal efficiency. The crystallographic texture by dry etching of titanium showed bactericidal effect on both Gram-positive and Gramnegative bacteria.