Role of Conjugative Elements in the Evolution of the Multidrug-Resistant Pandemic Clone Streptococcus pneumoniaeSpain23F ST81
Role of Conjugative Elements in the Evolution of the Multidrug-Resistant Pandemic Clone Streptococcus pneumoniaeSpain23F ST81
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DOI：
10.1128/jb.01343-08
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发表时间：
2009-03-01
影响因子：
3.2
通讯作者：
Mitchell, Tim J.
中科院分区：
文献类型：
--
作者：
Croucher, Nicholas J.;Walker, Danielle;Mitchell, Tim J.
肺炎链球菌是一种人类共生体和病原体，能够引起各种疾病，每年在世界范围内导致100多万人死亡。肺炎链球菌（Spain23F）序列81型谱系是最早被确认的大流行克隆之一，在20世纪90年代末，美国近40%的青霉素耐药肺炎球菌感染是由它引起的。对一个代表性菌株的染色体序列进行分析，并与其他可用的基因组进行比较，表明整合和结合元件在肺炎球菌的进化中发挥作用，特别是在多药耐药的西班牙23F ST81谱系的出现中。染色体内一些最近获得的基因座似乎编码了与抗菌化合物产生或免疫有关的蛋白质，这可能有助于该菌株在鼻咽定植方面的熟练程度。然而，将需要对其他大流行克隆进行进一步测序，以确定这些毒株是否具有导致其在国际上取得成功的任何共同特征。
Streptococcus pneumoniae is a human commensal and pathogen able to cause a variety of diseases that annually result in over a million deaths worldwide. The S. pneumoniae(Spain23F) sequence type 81 lineage was among the first recognized pandemic clones and was responsible for almost 40% of penicillin-resistant pneumococcal infections in the United States in the late 1990s. Analysis of the chromosome sequence of a representative strain, and comparison with other available genomes, indicates roles for integrative and conjugative elements in the evolution of pneumococci and, more particularly, the emergence of the multidrug-resistant Spain 23F ST81 lineage. A number of recently acquired loci within the chromosome appear to encode proteins involved in the production of, or immunity to, antimicrobial compounds, which may contribute to the proficiency of this strain at nasopharyngeal colonization. However, further sequencing of other pandemic clones will be required to establish whether there are any general attributes shared by these strains that are responsible for their international success.