Sexual functioning in long-term breast cancer survivors treated with adjuvant chemotherapy
Sexual functioning in long-term breast cancer survivors treated with adjuvant chemotherapy
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DOI：
10.1023/a:1019953027596
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发表时间：
2002-10-01
影响因子：
3.8
通讯作者：
Cox, CE
中科院分区：
文献类型：
--
作者：
Broeckel, JA;Thors, CL;Cox, CE
背景。之前的报告表明，性功能问题在长期（> 5 年）乳腺癌幸存者中可能很常见。为了进一步研究这个问题，我们检查了至少 5 年前诊断出患有乳腺癌并接受辅助化疗的女性以及年龄匹配的无癌症病史女性的对照组的性功能的特征和相关性。患者和方法。参与者包括 58 名平均年龄为 7.65 岁被诊断患有乳腺癌的女性和 61 名没有癌症病史的女性。所有参与者均完成了性功能、婚姻功能、抑郁、疲劳和更年期症状的标准化自我报告测量。结果。与无癌症病史的女性相比，长期乳腺癌幸存者的性功能较差（P小于或等于0.01），其特点是更缺乏性兴趣，无法放松和享受性爱，难以被唤起，难以达到性高潮。其他分析表明，阴道干燥的严重程度与长期乳腺癌幸存者的性功能较差显着相关（P 小于或等于 0.05），并介导了群体成员身份（乳腺癌幸存者与非癌症比较对象）和性功能之间的关系。结论。这些发现证实并扩展了先前关于长期乳腺癌幸存者性功能受损的报告。结果进一步表明，缓解阴道干燥应该是改善乳腺癌长期幸存者性功能的重要组成部分。
Background. Previous reports suggest that problems in sexual functioning may be common among long-term (>5 years) breast cancer survivors. To investigate this issue further, we examined the characteristics and correlates of sexual functioning in women diagnosed with breast cancer at least 5 years previously and treated with adjuvant chemotherapy and in an age-matched comparison group of women with no history of cancer.Patients and methods. Participants were 58 women initially diagnosed with breast cancer at an average of 7.65 years previously and 61 women with no history of cancer. All participants completed standardized self-report measures of sexual functioning, marital functioning, depression, fatigue, and menopausal symptoms.Results. Compared with women with no history of cancer, long-term breast cancer survivors reported worse sexual functioning (P less than or equal to 0.01), characterized by greater lack of sexual interest, inability to relax and enjoy sex, difficulty becoming aroused, and difficulty achieving an orgasm. Additional analyses indicated that severity of vaginal dryness was significantly (P less than or equal to 0.05) related to poorer sexual functioning among long-term breast cancer survivors and mediated the relationship between group membership (breast cancer survivor v.s. noncancer comparison subject) and sexual functioning.Conclusions. These findings confirm and extend previous reports of impaired sexual functioning among long-term breast cancer survivors. Results further suggest that relief of vaginal dryness should be an essential component of efforts to improve sexual functioning among long-term breast cancer survivors.