THE NEURAL CELL-ADHESION MOLECULE (NCAM) AS A REGULATOR OF CELL-CELL INTERACTIONS
THE NEURAL CELL-ADHESION MOLECULE (NCAM) AS A REGULATOR OF CELL-CELL INTERACTIONS
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DOI：
10.1126/science.3281256
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发表时间：
1988-04-01
期刊：
影响因子：
56.9
通讯作者：
SUNSHINE, J
中科院分区：
文献类型：
--
作者：
RUTISHAUSER, U;ACHESON, A;SUNSHINE, J
神经细胞粘附分子（NCAM）可以影响许多不同的细胞间事件，包括连接通讯，轴突与通路和靶点的关联，以及改变神经递质酶水平的信号。这些多效性效应似乎反映了NCAM调节启动其他分子之间特异性相互作用所需的膜-膜接触的能力。这种调节可以通过NCAM表达或多聚唾液酸（PSA）分子含量的变化发生。当表达具有低PSA含量的NCAM时，粘附增加并触发接触依赖性事件。相比之下，NCAM PSA的大排除体积可以通过阻碍整体膜附着来抑制细胞-细胞相互作用。
The neural cell adhesion molecule (NCAM) can influence a number of diverse intercellular events, including junctional communication, the association of axons with pathways and targets, and signals that alter levels of neurotransmitter enzymes. These pleiotropic effects appear to reflect the ability of NCAM to regulate membrane-membrane contact required to initiate specific interactions between other molecules. Such regulation can occur through changes in either NCAM expression or the molecule''s content of polysialic acid (PSA). When NCAM with a low PSA content is expressed, adhesion is increased and contact-dependent events are triggered. In contrast, the large excluded volume of NCAM PSA can inhibit cell-cell interactions through hindrance of overall membrane apposition.