Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage
Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage
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DOI：
10.3389/fmicb.2015.01037
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发表时间：
2015-10-01
影响因子：
5.2
通讯作者：
Paessler, Slobodan
中科院分区：
文献类型：
--
作者：
Manning, John T.;Forrester, Naomi;Paessler, Slobodan
以前从象牙海岸和马里输入到英国的拉沙热病例，以及在马里境内的Mastomys natalensis种群中检测到拉沙病毒（LASV），导致LF流行地区正在扩大的建议。最初的系统发育分析安排分离自马里和象牙海岸的经典谱系IV分离自塞拉利昂，几内亚和利比里亚。全基因组序列的可用性继续增加，允许从马里和象牙海岸的分离物与其他现有分离物进行更完整的系统发育比较。在这项研究中，我们利用贝叶斯方法来推断每个LASV分离株的人口统计学历史，其中完整的序列是可用的。我们的研究结果表明，从马里和象牙海岸组的分离株分离的谱系IV，包括一个独特的第五谱系。据估计，第四和第五谱系的分裂发生在大约200-300年前，这与西非的殖民时期相吻合。
Previous imported cases of Lassa fever (LF) into the United Kingdom from the Ivory Coast and Mali, as well as the detection of Lassa virus (LASV) among the Mastomys natalensis population within Mali has led to the suggestion that the endemic area for LF is expanding. Initial phylogenetic analyses arrange isolates from Mali and the Ivory Coast separately from the classical lineage IV isolates taken from Sierra Leone, Guinea, and Liberia. The availability of full genome sequences continues to increase, allowing for a more complete phylogenetic comparison of the isolates from Mali and the Ivory Coast to the other existing isolates. In this study, we utilized a Bayesian approach to infer the demographic histories of each LASV isolate for which the full sequence was available. Our results indicate that the isolates from Mali and the Ivory Coast group separately from the isolates of lineage IV, comprising a distinct fifth lineage. The split between lineages IV and V is estimated to have occurred around 200-300 years ago, which coincides with the colonial period of West Africa.