Force transduction by cadherin adhesions in morphogenesis.
Force transduction by cadherin adhesions in morphogenesis.
复制标题
DOI：
10.12688/f1000research.18779.1
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Gloerich, Martijn
中科院分区：
文献类型：
--
作者：
Pannekoek, Willem-Jan;de Rooij, Johan;Gloerich, Martijn
在形态发生过程中，机械力驱动组织的重塑。这依赖于基于钙粘附素的粘连连接在细胞之间的力传递，粘连连接连接相邻细胞的产生力的肌球蛋白细胞骨架。此外，钙粘附素粘连的成分采用力依赖的构象，导致粘连连接的组成发生变化，从而使机械力能够转化为细胞内的反应。钙粘附素的机械转导可以介导细胞间黏附的加强以抵抗外力，但也可以诱导生化信号来调节细胞的行为或直接重塑细胞间的黏附以使细胞重排。通过机械力的传递和转导，钙粘附素黏附协调了集体细胞迁移、细胞分裂和细胞嵌入等形态发生过程中的细胞行为。在这里，我们回顾了最新的进展，我们了解这一核心作用的钙粘附素在力依赖的调控的形态发生。
Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons of neighboring cells. Moreover, components of cadherin adhesions adopt force-dependent conformations that induce changes in the composition of adherens junctions, enabling transduction of mechanical forces into an intracellular response. Cadherin mechanotransduction can mediate reinforcement of cell-cell adhesions to withstand forces but also induce biochemical signaling to regulate cell behavior or direct remodeling of cell-cell adhesions to enable cell rearrangements. By transmission and transduction of mechanical forces, cadherin adhesions coordinate cellular behaviors underlying morphogenetic processes of collective cell migration, cell division, and cell intercalation. Here, we review recent advances in our understanding of this central role of cadherin adhesions in force-dependent regulation of morphogenesis.