Cortical correlates of neuromotor development in healthy children
Cortical correlates of neuromotor development in healthy children
复制标题
健康儿童神经运动发育的皮质相关性
DOI：
10.1016/s1388-2457(03)00130-5
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发表时间：
2003-09-01
影响因子：
4.7
通讯作者：
Wassermann, EM
中科院分区：
文献类型：
--
作者：
Garvey, MA;Ziemann, U;Wassermann, EM
目的：探讨儿童精细运动技能习得与运动皮质发育的关系。方法：对43名6~26岁健康右利手受试者进行手指敲击速度和镜面运动的测量。在记录右侧和左侧第一背侧骨间肌表面肌电活动的同时，我们在每个运动皮质的手部区域进行了局部经颅磁刺激(TMS)。测量运动诱发电位(MEP)阈值、同侧(ISP)和对侧(CSP)静止期。结果：随着年龄的增长，手指运动速度加快，MEP阈值降低，ISP持续时间延长，潜伏期缩短。手指敲击速度随运动阈值和ISP潜伏期的降低而加快，但与CSP持续时间无关。所有受试者右侧大脑半球MEP阈值均高于左侧，右侧CSP持续时间长于左侧。10岁以下儿童左手镜面运动得分较高，左半球持续时间较长的ISP较少。结论：手指敲击技能的成熟与运动阈值和ISP潜伏期的发育变化密切相关。有必要研究这些措施与运动障碍儿童的其他神经运动技能之间的关系。意义：TMS可以为儿童神经发育的某些功能方面提供重要的见解。(C)2003年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To examine the relationship between acquisition of fine motor skills in childhood and development of the motor cortex.Methods: We measured finger tapping speed and mirror movements in 43 healthy right-handed subjects (6-26 years of age). While recording surface electromyographic activity from right and left first dorsal interosseus, we delivered focal transcranial magnetic stimulation (TMS) over the hand areas of each motor cortex. We measured motor evoked potential (MEP) threshold, and ipsilateral (iSP) and contralateral (CSP) silent periods.Results: As children got older, finger speeds got faster, MEP threshold decreased, iSP duration increased and latency decreased. Finger tapping speed got faster as motor thresholds and iSP latency decreased, but was unrelated to CSP duration. In all subjects right hemisphere MEP thresholds were higher than those on the left and duration of right hemisphere CSP was longer than that on the left. Children under 10 years of age had higher left hand mirror movement scores, and fewer left hemisphere iSPs which were of longer duration.Conclusions: Maturation of finger tapping skills is closely related to developmental changes in the motor threshold and iSP latency. Studies are warranted to explore the relationship between these measures and other neuromotor skills in children with motor disorders.Significance: TMS can provide important insights into certain functional aspects of neurodevelopment in children. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.