Evidence for amelioration of steroid-mediated immunosuppression by ascorbic acid.
Evidence for amelioration of steroid-mediated immunosuppression by ascorbic acid.
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抗坏血酸改善类固醇介导的免疫抑制的证据。
DOI：
10.3382/ps.0631262
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发表时间：
1984
期刊：
影响因子：
4.4
通讯作者：
J. Thaxton
中科院分区：
文献类型：
--
作者：
S. Pardue;J. Thaxton
本研究通过四个实验来确定补充抗坏血酸（AA）是否能改善外源性皮质醇（COL）引起的免疫抑制。在饲料中以0和1000 ppm的水平提供补充AA。COL的管理显着降低血浆AA在0和10天postmunization，和AA补充升高血浆AA在这两个时间。皮质醇处理的鸡表现出显着减少凝集素的绵羊红细胞，但不是布鲁氏菌。补充AA显着改善与外源性COL相关的免疫抑制，并可能作为一种抗免疫抑制剂在鸡。
Four experiments were conducted to determine if supplemental ascorbic acid (AA) would ameliorate the immunosuppression induced by exogenous cortisol (COL). Supplemental AA was provided in the diets at levels of 0 and 1000 ppm. Administration of COL significantly lowered plasma AA at both 0 and 10 days postimmunization, and AA supplementation elevated plasma AA at both times. Cortisol-treated chicks exhibited significantly reduced agglutinins to sheep red blood cells but not to Brucella abortus. Supplemental AA significantly ameliorated the immunosuppression associated with exogenous COL and may serve as an antiimmunosuppressive agent in the chicken.