Plasma natriuretic peptide levels and the risk of cardiovascular events and death
Plasma natriuretic peptide levels and the risk of cardiovascular events and death
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DOI：
10.1056/nejmoa031994
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发表时间：
2004-02-12
影响因子：
158.5
通讯作者：
Vasan, RS
中科院分区：
文献类型：
--
作者：
Wang, TJ;Larson, MG;Vasan, RS
背景：利钠肽是参与容量稳态和心血管重塑的反调节激素。对于明显无症状的人血浆利尿钠肽水平的预后意义尚未确定。方法：我们对 3346 名无心力衰竭的人进行了前瞻性研究。使用比例风险回归，我们检查了血浆 B 型利钠肽和 N 端心房利钠肽前体与全因死亡、首次重大心血管事件、心力衰竭、心房颤动、中风或短暂性脑缺血发作以及冠心病的风险之间的关系。 结果：在平均 5.2 年的随访期间，119 名参与者死亡，79 名参与者发生首次心血管事件。调整心血管危险因素后，log B 型利钠肽水平每增加 1 个 SD，死亡风险就会增加 27% (P=0.009)，首次心血管事件的风险就会增加 28% (P=0.03)，心力衰竭的风险就会增加 77% (P=0.03)。
Background: The natriuretic peptides are counterregulatory hormones involved in volume homeostasis and cardiovascular remodeling. The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established.Methods: We prospectively studied 3346 persons without heart failure. Using proportional-hazards regression, we examined the relations of plasma B-type natriuretic peptide and N-terminal pro-atrial natriuretic peptide to the risk of death from any cause, a first major cardiovascular event, heart failure, atrial fibrillation, stroke or transient ischemic attack, and coronary heart disease.Results: During a mean follow-up of 5.2 years, 119 participants died and 79 had a first cardiovascular event. After adjustment for cardiovascular risk factors, each increment of 1 SD in log B-type natriuretic peptide levels was associated with a 27 percent increase in the risk of death (P=0.009), a 28 percent increase in the risk of a first cardiovascular event (P=0.03), a 77 percent increase in the risk of heart failure (P