Repetitive finger movement performance differs among Parkinson's disease, Progressive Supranuclear Palsy, and spinocerebellar ataxia.
Repetitive finger movement performance differs among Parkinson's disease, Progressive Supranuclear Palsy, and spinocerebellar ataxia.
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DOI：
10.1186/s40734-014-0015-y
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Hass, Chris J
中科院分区：
文献类型：
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作者：
Stegemoller, Elizabeth L;Uzochukwu, Jennifer;Hass, Chris J
背景：区分运动障碍对于适当的治疗、预后和临床试验至关重要。在临床试验中，这一点尤其重要，因为纳入不适当诊断的参与者可能会稀释效果。在疾病的早期持续阶段，疾病通常具有重叠的临床特征，例如重复手指运动的损伤，使得诊断具有挑战性。本试点研究的目的是检查和比较重复手指运动的表现，在参与者诊断为特发性帕金森氏病，进行性核上性麻痹，脊髓小脑共济失调。方法：参与者完成了不受约束的食指屈曲/伸展运动（即手指水龙头）的时间与增量声学音。运动速率，运动幅度，变异系数的措施进行了比较groups.RESULTS：组间的显着差异，揭示了在更快的音调速率的运动速率。帕金森氏症患者的敲击速度往往比音调速度快，而进行性核上性麻痹和脊髓小脑共济失调患者的敲击速度往往较慢。运动幅度无显着差异，但脊髓小脑共济失调的参与者表现出更大的差异幅度比参与者与帕金森氏diseases.CONCLUSION：定量分析重复手指运动性能在更快的速度可能有助于区分帕金森氏病，进行性核上性麻痹和脊髓小脑共济失调。
BACKGROUND: Differentiating movement disorders is critical for appropriate treatment, prognosis, and for clinical trials. In clinical trials this is especially important as effects can be diluted by inclusion of inappropriately diagnosed participants. In early disease duration phases, disorders often have overlapping clinical features, such as impairments in repetitive finger movement, making diagnosis challenging. The purpose of this pilot study was to examine and compare repetitive finger movement performance in participants diagnosed with idiopathic Parkinson's disease, Progressive Supranuclear Palsy, and spinocerebellar ataxias.METHODS: Participants completed an unconstrained index finger flexion/extension movement (i.e. finger tap) in time with an incremental acoustic tone. Measures of movement rate, movement amplitude, and coefficient of variation were compared among groups.RESULTS: Significant differences between groups were revealed for movement rate at faster tone rates. Participants with Parkinson's disease tended to tap faster than the tone rate while participants with Progressive Supranuclear Palsy and spinocerebellar ataxia tended to tap slower. No significant differences were revealed for movement amplitude, but participants with spinocerebellar ataxia demonstrated greater variance in amplitude than participants with Parkinson's disease.CONCLUSION: Quantitative analysis of repetitive finger movement performance at faster rates may be helpful to differentiate Parkinson's Disease, Progressive Supranuclear Palsy and spinocerebellar ataxia.