Antioxidant Status in Hyperthyroid Cats before and after Radioiodine Treatment
Antioxidant Status in Hyperthyroid Cats before and after Radioiodine Treatment
复制标题
DOI：
10.1111/j.1939-1676.2012.00903.x
复制
发表时间：
2012-05-01
影响因子：
2.6
通讯作者：
Trepanier, L. A.
中科院分区：
文献类型：
--
作者：
Branter, E.;Drescher, N.;Trepanier, L. A.
甲状腺功能亢进患者体内存在可逆的抗氧化剂耗竭，而抗氧化剂耗竭会增加大鼠甲巯咪唑中毒的风险。目的探讨甲状腺功能亢进症猫血抗氧化剂和尿异前列腺素浓度是否存在异常，以及放射性碘治疗后是否可逆。确定抗氧化剂异常是否与特异质他巴唑中毒有关。动物甲状腺功能亢进猫接受放射性碘治疗（n=44），健康成年对照猫（n=37）。方法前瞻性、对照性、观察性研究。将甲亢猫的红细胞谷胱甘肽（GSH）、血浆抗坏血酸（AA）、血浆游离视黄醇（维生素A）、α-生育酚（维生素E）和尿游离8-异前列腺素与健康猫和治疗后2个月的甲亢猫进行比较。结果甲状腺功能亢进猫的血液抗氧化剂（平均GSH 1.6 +/- 0.3mM; AA 12.8 +/- 4.9 μ M，维生素E 25 +/- 14 μ g/mL）与对照组（GSH 1.4 +/- 0.4mM; AA 15.0 +/- 6.6 μ M，维生素E 25 +/- 17 μ g/mL）相比无显著差异。与对照组（169 +/-82 pg/mg; P=.006）相比，甲状腺功能亢进猫（292 +/-211 pg/mg肌酐）的尿异前列腺素增加，特别是在USG的甲状腺功能亢进猫中
Background Reversible antioxidant depletion is found in hyperthyroid humans, and antioxidant depletion increases the risk of methimazole toxicosis in rats. Objectives To determine whether abnormalities in concentrations of blood antioxidants or urinary isoprostanes were present in hyperthyroid cats, and were reversible after radioiodine treatment. To determine whether or not antioxidant abnormalities were associated with idiosyncratic methimazole toxicosis. Animals Hyperthyroid cats presented for radioiodine treatment (n=44) and healthy mature adult control cats (n=37). Methods Prospective, controlled, observational study. Red blood cell glutathione (GSH), plasma ascorbate (AA), plasma free retinol (vitamin A), a-tocopherol (vitamin E), and urinary free 8-isoprostanes in hyperthyroid cats were compared to healthy cats and to hyperthyroid cats 2months after treatment. Results Blood antioxidants were not significantly different in hyperthyroid cats (mean GSH 1.6 +/- 0.3mM; AA 12.8 +/- 4.9 mu M, and vitamin E, 25 +/- 14 mu g/mL) compared to controls (GSH 1.4 +/- 0.4mM; AA 15.0 +/- 6.6 mu M, and vitamin E, 25 +/- 17 mu g/mL). Urinary isoprostanes were increased in hyperthyroid cats (292 +/- 211pg/mg creatinine) compared to controls (169 +/- 82pg/mg; P=.006), particularly in hyperthyroid cats with a USG