Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) in Gastric Cancer.
Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) in Gastric Cancer.
复制标题
DOI：
--
复制
发表时间：
2015-06
影响因子：
2
通讯作者：
Akiko Shida;N. Futawatari;Takashi Fukuyama;Y. Ichiki;Yoshihito Takahashi;Y. Nishi;Noritada Kobayashi;H. Yamazaki;M. Watanabe
中科院分区：
文献类型：
--
作者：
Akiko Shida;N. Futawatari;Takashi Fukuyama;Y. Ichiki;Yoshihito Takahashi;Y. Nishi;Noritada Kobayashi;H. Yamazaki;M. Watanabe
肿瘤相关抗原Kita-Kyushu lung cancer antigen-1（KK-LC-1）在正常组织中不表达，除了睾丸，在非小细胞肺癌中也不表达。本研究证实KK-LC-1在胃癌中表达。材料与方法我们分析了49例胃癌手术标本中KK-LC-1和癌/睾丸抗原（CTA）的表达。采用逆转录-聚合酶链反应检测KK-LC-1和CTA的表达。结果胃癌组织中存在KK-LC-1的表达。在49例食管癌标本中，KK-LC-1、MAGE-A1、MAGE-A3和纽约食管鳞状细胞癌-1（NY-ESO-1）的阳性表达分别为40例（81.6%）、17例（34.7%）、22例（44.9%）和8例（16.3%）。结论KK-LC-1属于CTA。KK-LC-1的表达频率高于其他CTA。KK-LC-1可能成为胃癌免疫治疗和诊断的有效靶点。
BACKGROUND The tumor-associated antigen Kita-Kyushu lung cancer antigen-1 (KK-LC-1) has been reported as not being expressed in normal tissues, except for the testis, and in the setting of non-small cell lung cancer. The present study demonstrated that KK-LC-1 is expressed in gastric cancer. MATERIALS AND METHODS We analyzed the expression of KK-LC-1 and cancer/testis antigens (CTAs) in surgical specimens of 49 gastric carcinomas. The expression of KK-LC-1 and CTAs was assessed using reverse transcription-polymerase chain reaction. RESULTS KK-LC-1 expression was observed in gastric carcinomas. The number of lesions with expression of KK-LC-1, Melanoma antigen gene encoding-A1 (MAGE-A1), MAGE-A3 and New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) was 40 (81.6%), 17 (34.7%), 22 (44.9%) and 8 (16.3%) out of the 49 specimens, respectively. CONCLUSION KK-LC-1 should be categorized as a CTA. The frequency of KK-LC-1 expression was higher than that of the other CTAs. KK-LC-1 might be a useful target for immunotherapy and in diagnosis of gastric cancer.