Transcriptional control of T cell development.
Transcriptional control of T cell development.
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DOI：
10.1016/s0952-7915(00)00091-1
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发表时间：
2000-06
影响因子：
7
通讯作者：
B. Osborne
中科院分区：
文献类型：
--
作者：
B. Osborne
T细胞发育的转录控制是一个复杂且快速发展的研究领域。最近的进展揭示了几种转录因子在T细胞定型、分化和选择中的关键作用。特别是，已经描述了E蛋白以及Notch信号通路成员的新作用。此外，Ikaros在染色质重塑中的独特功能揭示了一种新的转录控制机制。
Transcriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted.