Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation
Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation
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用于超高对比度荧光成像和热化疗协同肿瘤消融的双重 pH/还原响应囊泡
DOI：
10.1021/acsnano.5b02843
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发表时间：
2015
期刊：
影响因子：
17.1
通讯作者：
Chen Huabing
中科院分区：
文献类型：
--
作者：
Zhu Aijun;Miao Ke;Deng Yibin;Ke Hengte;He Hui;Yang Tao;Guo Miao;Li Yanli;Guo Zhengqing;Wang Yangyun;Yang Xiangliang;Zhao Youliang;Chen Huabing
智能纳米载体作为治疗诊断学领域中的成像和治疗剂的纳米级载体特别令人感兴趣。在此，我们报告的双重pH/还原响应的三元共聚物囊泡的单分散的尺寸分布，这是通过组装缩醛和二硫键功能化的星星与近红外菁染料和抗癌药物。该囊泡纳米结构表现出多种治疗诊断特征，包括响应于pH/还原刺激的按需药物释放、花青染料的增强的光热转化效率、以及从溶酶体到细胞质的有效药物转运，以及优选的细胞摄取和生物分布。这些多种治疗诊断特征导致超高对比度荧光成像和热化疗协同肿瘤消融。双重刺激响应囊泡代表了用于增强癌症成像和治疗的通用治疗诊断方法。
Smart nanocarriers are of particular interest as nanoscale vehicles of imaging and therapeutic agents in the field of theranostics. Herein, we report dually pH/reduction-responsive terpolymeric vesicles with monodispersive size distribution, which are constructed by assembling acetal- and disulfide-functionalized star terpolymer with near-infrared cyanine dye and anticancer drug. The vesicular nanostructure exhibits multiple theranostic features including on-demand drug releases responding to pH/reduction stimuli, enhanced photothermal conversion efficiency of cyanine dye, and efficient drug translocation from lysosomes to cytoplasma, as well as preferable cellular uptakes and biodistribution. These multiple theranostic features result in ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. The dually stimuli-responsive vesicles represent a versatile theranostic approach for enhanced cancer imaging and therapy.