Glucocorticoids can arm macrophages for innate immune battle.
Glucocorticoids can arm macrophages for innate immune battle.
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糖皮质激素可以武装巨噬细胞进行先天免疫战斗。
DOI：
10.1016/j.bbi.2009.10.004
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Sapolsky,RobertM
中科院分区：
文献类型：
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作者：
Sorrells,ShawnF;Sapolsky,RobertM
尽管范式转换是戏剧性的，但科学更多的是逐个像素地添加或替换事实的点式过程。这种替代可能是一场艰苦的战斗，基本上包括说，“是的，事情就是这样运作的……但也不完全是。“随着足够多的替换，整体情况发生了变化。这种变化现在正在发生在神经炎症的调节器上，Frank等人在XXX页上的工作(Frank等人，2009)是这种变化的重要贡献。修正主义关注糖皮质激素(GC)对炎症的影响。GCS是肾上腺释放的类固醇。内源性GC，皮质醇和皮质酮(CORT)，接近应激生理学家的心脏。这些GC在应激过程中分泌，对身体对短期应激源的适应性反应以及对慢性应激的致病性至关重要。与此同时，合成类固醇，如泼尼松和地塞米松，接近医生的心脏(Sapolsky等人，2000年)，原因当然是GC抑制炎症的能力。这些效应涵盖了从收紧血脑屏障到诱导淋巴细胞凋亡和抑制核因子-κB活性的各个方面。这些作用是合成GC在包括神经学在内的医学中广泛使用的基础(McEwen等人，1997年)。
Despite the drama of the paradigm shift, science is more the pointillist process of adding or replacing facts, pixel by pixel. This replacement can be an uphill battle, basically consisting of saying,“Well yes, this is how things work... but not exactly.” And with enough of those replacements, the overall picture changes. Such a change is occurring now with regulators of neuroinflammation, and the work of Frank et al., on page XXX (Frank et al., 2009) is an important contribution to this changing picture.The revisionism concerns the effects of glucocorticoids (GCs) on inflammation. GCs are steroids released from the adrenal gland. The endogenous GCs, cortisol and corticosterone (CORT), are near to the hearts of stress physiologists. These GCs are secreted during stress and are central to the body's adaptive response to short-term stressors as well as to the pathogenicity of chronic stress. Meanwhile, synthetic steroids such as prednisone and dexamethasone, are near to the hearts of physicians (Sapolsky et al., 2000) The reason, of course, is the ability of GCs to inhibit inflammation. These effects cover the gamut from tightening of the blood brain barrier, to induction of apoptosis in lymphocytes and to inhibition of NF-κB activity. These actions are the foundation for the vast use of synthetic GCs in medicine, including neurology (McEwen et al., 1997).