Reassessing the presence of Candida albicans in denture-related stomatitis
Reassessing the presence of Candida albicans in denture-related stomatitis
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DOI：
10.1067/moe.2003.44
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发表时间：
2003-01-01
期刊：
影响因子：
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通讯作者：
Deslauriers, N
中科院分区：
文献类型：
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作者：
Barbeau, J;Séguin, J;Deslauriers, N
客观的。本研究的目的是根据改良的牛顿分类重新评估白色念珠菌和假牙相关性口腔炎之间的联系，该分类反映了炎症的经典类型以及组织受影响的程度。研究设计。对两组假牙佩戴者进行了与假牙相关的口腔炎的评估。确定了假牙上酵母菌的存在和数量、存在的念珠菌种类的鉴定以及菌斑覆盖量。研究中包括了假定的危险因素。对这些变量与口腔炎之间的关系进行统计分析。结果。根据牛顿分类，假牙上酵母的存在与受试者是否患有口腔炎无关。但根据我们的分类，无论牛顿类型如何，在炎症最广泛的个体的假牙上发现了更高的酵母携带者患病率、酵母菌落数量和菌斑覆盖率。在评估的危险因素中，夜间佩戴假牙和吸烟与最广泛的炎症有关。我们还证明，在义齿相关性口腔炎中，白色念珠菌的存在以及不同念珠菌种类的共存更为常见。差异有统计学意义。结论。根据我们修改后的分类，对不同假牙相关性口腔炎类别的微生物数据进行统计分析表明，假牙上酵母菌的存在与炎症程度显着相关，而不是与牛顿型相关。我们的研究结果表明，口腔炎的炎症过程有利于念珠菌的定植。这些结果可能对该疾病的诊断和治疗产生新的影响。
Objective. The aim of this study was to reevaluate the link between Candida albicans and denture-related stomatitis according to a modified Newton classification, which reflects the classic types of inflammation as well as the extent to which the tissue is affected.Study design. Two groups of denture wearers were evaluated for denture-related stomatitis. The presence and number of yeasts on the dentures, the identification of the Candida species present, and the amount of plaque coverage were determined. Putative risk factors were included in the study. Relations between these variables and stomatitis were analyzed statistically.Results. According to Newton's classification, the presence of yeast on the denture was not linked to whether subjects had stomatitis. But with our classification, higher prevalence of yeast carriers, yeast colony number, and plaque coverage were found on the dentures of individuals with the most extensive inflammation, regardless of Newton type. Among risk factors evaluated, wearing dentures at night and smoking were associated with the most extensive inflammation. We also demonstrated that the presence of C albicans as well as the cohabitation of different Candida species was more frequent in denture-related stomatitis. The differences were statistically significant.Conclusions. Statistical analysis of microbiologic data from different denture-related stomatitis categories according to our modified classification showed that the presence of yeast on dentures was significantly associated with the extent of the inflammation, rather than with the Newton type. Our findings suggest that the inflammatory process of stomatitis favors the colonization of Candida. These results could have new implications for diagnosis and management of the condition.