Determinants of arterial stiffness in an apparently healthy population over 60 years
Determinants of arterial stiffness in an apparently healthy population over 60 years
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DOI：
10.1038/sj.jhh.1002072
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发表时间：
2006-10-01
影响因子：
2.7
通讯作者：
Benetos, A.
中科院分区：
文献类型：
--
作者：
Alecu, C.;Gueguen, R.;Benetos, A.
脉搏波传导速度（PWV）是一种无创性和可重复性的方法，可以预测心血管疾病的发病率和死亡率。动脉硬化的主要决定因素在年轻和中年人群中得到了很好的确立，但在老年人中则少得多。本研究的目的是描述老年人动脉僵硬度的决定因素。该研究包括221名1944年以前出生的志愿受试者（平均年龄67.4 ± 5.0岁），他们在南希的“预防医学中心”进行了标准健康检查。动脉僵硬度的评估是通过测量颈动脉-股动脉PWV与PulsePen自动装置。在同一天评价临床和生物学参数。在207名受试者（94名女性）中进行了有效的测量和分析。平均PWV为9.39 +/- 2.64 m/s。男性PWV值高于女性（9.99 ± 2.56 vs 8.66 ± 2.56，P
Arterial stiffness assessed by the pulse wave velocity (PWV), a non-invasive and reproducible method, predicts cardiovascular morbidity and mortality. The main determinants of arterial stiffness are well established in younger and middle-aged populations, but much less in the elderly. The aim of this study was to describe the determinants of arterial stiffness in elderly apparently healthy subjects. The study included 221 voluntary subjects born before 1944 ( mean age 67.4 +/- 5.0 years), who had a standard health check-up at the 'Centre de Medecine Preventive' of Nancy. Arterial stiffness was evaluated by measuring the carotid - femoral PWV with the PulsePen automatic device. Clinical and biological parameters were evaluated at the same day. Measurements were valid and analysed in 207 subjects ( 94 women). Mean PWV was 9.39 +/- 2.64 m/s. Men showed higher PWV values than women (9.99 +/- 2.56 vs 8.66 +/- 2.56, P