Esterified estrogens with and without methyltestosterone decrease arterial LDL metabolism in cynomolgus monkeys.
Esterified estrogens with and without methyltestosterone decrease arterial LDL metabolism in cynomolgus monkeys.
复制标题
含有或不含甲基睾酮的酯化雌激素可降低食蟹猴的动脉低密度脂蛋白代谢。
DOI：
10.1161/01.atv.16.12.1473
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Adams,MR
中科院分区：
文献类型：
--
作者：
Wagner,JD;Zhang,L;Williams,JK;Register,TC;Ackerman,DM;Wiita,B;Clarkson,TB;Adams,MR
尽管流行病学和实验证据都表明雌激素替代疗法可以降低冠心病的风险，但这种有益效果的机制在很大程度上是未知的。此外，在雌激素替代疗法中加入黄体酮或雄激素也是值得关注的。本研究的目的是研究单独使用酯化雌激素或与雄激素联合使用对切除卵巢的雌性食蟹猴动脉LDL代谢和早期动脉粥样硬化的影响。在尸检前24小时注射双标记LDL评估动脉LDL代谢。与对照组相比，两个治疗组的动脉LDL降解降低64% ~ 84%，胸主动脉胆固醇酯含量降低约50%。此外，经硫代巴比妥酸反应评估，接受酯化雌激素治疗的动物主动脉脂质过氧化产物显著降低，雌激素-雄激素联合治疗也有类似趋势。两种治疗均降低了含载脂蛋白的血浆浓度，降低了LDL颗粒大小，并增加了全身LDL分解代谢。动脉低密度脂蛋白代谢降低、动脉脂质过氧化降低和血浆脂蛋白代谢改善的联合作用可能解释了雌激素对冠心病的一些保护作用，并表明雌激素和雄激素的联合作用是有益的。
Although both epidemiological and experimental evidence suggests that estrogen replacement therapy reduces the risk of coronary heart disease, the mechanisms for this beneficial effect are largely unknown. Furthermore, the addition of progestins or androgens to estrogen replacement therapy is of concern. The objective of this study was to examine the effects of esterified estrogens alone or in combination with an androgen on arterial LDL metabolism and early atherogenesis in ovariectomized female cynomolgus monkeys. Arterial LDL metabolism was assessed by using dual-labeled LDL that was injected 24 hours before necropsy. Arterial LDL degradation was reduced by 64% to 84% and cholesteryl ester content was decreased by ≈50% in the thoracic aorta in both treatment groups compared with controls. In addition, aortic lipid peroxidation products, as assessed by thiobarbituric acid reaction, were significantly lower in animals treated with esterified estrogens, with a similar trend for combined estrogen-androgen treatment. Both treatments also reduced plasma concentrations of apoB-containing lipoproteins, reduced LDL particle size, and increased total-body LDL catabolism. The combination of decreased arterial LDL metabolism, decreased arterial lipid peroxidation, and improved plasma lipoprotein metabolism may explain some of the protective effects of estrogens on coronary heart disease and indicate that beneficial actions extend to a combination of estrogen and androgen.