Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: findings from the WHEL Study.
Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: findings from the WHEL Study.
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早期乳腺癌幸存者的体力活动、额外乳腺癌事件和死亡率：WHEL 研究的结果。
DOI：
10.1007/s10552-010-9714-3
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Pierce JP
中科院分区：
文献类型：
--
作者：
Bertram LA;Stefanick ML;Saquib N;Natarajan L;Patterson RE;Bardwell W;Flatt SW;Newman VA;Rock CL;Thomson CA;Pierce JP
研究表明，体力活动与乳腺癌生存率的提高有关，但没有研究检查了诊断后体力活动变化与乳腺癌预后之间的关系。本研究的目的是确定基线活动和1年活动变化是否与乳腺癌事件或死亡率相关。共有2，361名治疗后乳腺癌幸存者（I-III期）参加了一项饮食变化的随机对照试验，在基线和一年内完成了体力活动测量。计算每个时间点的体力活动变量（总体力活动、中等强度体力活动和对指南的依从性）。中位随访时间为7.1年。结局为浸润性乳腺癌事件和全因死亡率。基线时最活跃的女性死亡风险比最不活跃的女性低53%（HR = 0.47; 95% CI：0.26，0.84; p = 0.01）。遵守活动指南与死亡风险降低35%相关（HR = 0.65，95%CI：0.47，0.91; p <0.01）。无论是基线还是1年的活动变化都与额外的乳腺癌事件无关。较高的基线（治疗后）体力活动与生存率改善相关。然而，在接下来的一年中，活动的变化与结果无关。这些数据表明，长期的体力活动水平对乳腺癌预后很重要。
Research suggests that physical activity is associated with improved breast cancer survival, yet no studies have examined the association between post-diagnosis changes in physical activity and breast cancer outcomes. The aim of this study was to determine whether baseline activity and 1-year change in activity are associated with breast cancer events or mortality. A total of 2,361 post-treatment breast cancer survivors (Stage I–III) enrolled in a randomized controlled trial of dietary change completed physical activity measures at baseline and one year. Physical activity variables (total, moderate–vigorous, and adherence to guidelines) were calculated for each time point. Median follow-up was 7.1 years. Outcomes were invasive breast cancer events and all-cause mortality. Those who were most active at baseline had a 53% lower mortality risk compared to the least active women (HR = 0.47; 95% CI: 0.26, 0.84; p = .01). Adherence to activity guidelines was associated with a 35% lower mortality risk (HR = 0.65, 95% CI: 0.47, 0.91; p < .01). Neither baseline nor 1-year change in activity was associated with additional breast cancer events. Higher baseline (post-treatment) physical activity was associated with improved survival. However, change in activity over the following year was not associated with outcomes. These data suggest that long-term physical activity levels are important for breast cancer prognosis.
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DOI：
10.1158/1055-9965.epi-08-0531
发表时间：
2009-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Irwin ML;Varma K;Alvarez-Reeves M;Cadmus L;Wiley A;Chung GG;Dipietro L;Mayne ST;Yu H
通讯作者：
Yu H
DOI：
10.1158/1055-9965.epi-08-0595
发表时间：
2009-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Sternfeld B;Weltzien E;Quesenberry CP Jr;Castillo AL;Kwan M;Slattery ML;Caan BJ
通讯作者：
Caan BJ
影响因子：
2.3
作者：
Johnson-Kozlow, Marilyn;Rock, Cheryl L.;Pierce, John P.
通讯作者：
Pierce, John P.
影响因子：
120.7
作者：
Holmes, MD;Chen, WY;Colditz, GA
通讯作者：
Colditz, GA
影响因子：
45.3
作者：
Pierce, John P.;Stefanick, Marcia L.;Rock, Cheryl L.
通讯作者：
Rock, Cheryl L.