The impulses produced by sensory nerve endings. Part I.
The impulses produced by sensory nerve endings. Part I.
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DOI：
10.1113/jphysiol.1926.sp002273
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发表时间：
1926-03-01
影响因子：
5.5
通讯作者：
Adrian, ED
中科院分区：
文献类型：
--
作者：
Adrian, ED
描述了放大器与毛细管静电计结合使用的布置，并对感觉神经的动作电流进行了初步观察。作者对毛细管静电计的特性进行了批判性讨论，并强调与弦检流计相比，毛细管静电计不存在由运动系统惯性引起的失真。它的低灵敏度通过使用专门设计以免受外部电气和机械干扰的 3 管电阻电容耦合放大器来克服。该组合记录了 0.01 毫伏量级的电位快速变化。当附着的腓肠肌被不同的重量拉伸时，从青蛙的坐骨神经获得记录。通过对温度变化、频率、传导速率、时间关系、电极之间挤压以获得单相反应以及杀死神经的影响的研究表明，这些是伴随感觉脉冲通过的真实动作电流。振荡次数随拉伸程度而变化，随着持续时间的增加，振荡次数逐渐减少，大约 10 分钟后完全停止。在弱刺激下，振荡是相互隔离的，这一点以及它们的均匀性，得出这样的结论：没有多少纤维参与产生个体反应，可能只有 1 个。这些反应的大小与刺激的强度无关。在呼吸过程中从猫和兔子的迷走神经获得的动作电流显示出相应的频率和幅度的节律变化，并且只要肺部保持扩张，就会有稳定的脉冲流。感觉动作电流的其他记录是从猫的隐神经（当皮肤被捏时）和兔子的降心神经中获得的。
An arrangement for the use of an amplifier in conjunction with the capillary electrometer is described, with preliminary observations on the action currents of sensory nerves. The author gives a critical discussion of the properties of the capillary electrometer and emphasizes the absence of distortion caused by the inertia of the moving system, as compared with the string galvanometer. Its low sensitivity is overcome by the use of a 3-tube resistance-capacity coupled amplifier especially designed to be free from extraneous electrical and mechanical disturbances. The combination records rapid changes of potential of the order of 0.01 millivolt. Records were obtained from the sciatic nerve of the frog when the attached gastrocnemius muscle was stretched by various weights. That these are true action currents accompanying the passage of sensory impulses is shown by a study of the effects of temperature changes, the frequency, rate of conduction, time relation, crushing between electrodes to obtain monophasic responses, and killing the nerve. The number of oscillations varies with the degree of stretching and becomes less as the duration is increased, ceasing entirely after about 10 minutes. With weak stimuh the oscillations are isolated from one another, and this, along with their uniformity, leads to the conclusion that not many fibers are involved in producing the individual responses, probably only 1. The size of those responses bears no relation to the strength of the stimulus. Action currents obtained from the vagus nerve of the cat and rabbit during respiration show a corresponding rhythmic variation in frequency and amplitude and there is a steady flow of impulses as long as the lungs remain expanded. Other records of sensory action currents were obtained from the cat''s saphenous nerve when the skin was pinched, and from the cardiac depressor nerve in the rabbit.