Intrauterine growth restriction, brain-sparing effect, and neurotrophins
Intrauterine growth restriction, brain-sparing effect, and neurotrophins
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DOI：
10.1196/annals.1365.026
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Puchner, K-P.
中科院分区：
文献类型：
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作者：
Malamitsi-Puchner, Ariadne;Nikolaou, K. E.;Puchner, K-P.
宫内生长受限（IUGR）是指由于胎儿-胎盘-母体单位的解剖/功能疾病或障碍，胎儿未能实现其内在生长潜力。生长受限成功地平衡了减少的氧气输送和消耗;然而，慢性缺氧导致胎儿血流重新分配到主要器官（脑、心肌和肾上腺），即所谓的脑保护效应。神经营养蛋白家族包括四种结构相关的分子：神经生长因子（NGF）、脑源性神经营养因子（BDNF）、神经营养蛋白-3（NT-3）和神经营养蛋白-4（NT-4）。通过发挥神经保护作用，神经营养因子对出生前和出生后的大脑发育至关重要。基于这一假设，脑保护效应可能在足月IUGR婴儿中被激活，我们假设循环神经营养因子水平在IUGR和适合胎龄（阿加）婴儿之间不应该有差异。事实上，我们发现在两组中，循环NT-3，NT-4和BDNF水平没有差异，这一发现可能归因于脑保护效应的激活。相反，与IUGR组相比，阿加组的NGF水平更高。而IUGR组仅NGF水平与新生儿出生体重和定制百分位数呈正相关，且两者均低于IUGR组。
Intrauterine growth restriction (IUGR) is failure of the fetus to achieve his or her intrinsic growth potential, due to anatomical/functional diseases or disorders in the feto-placental-maternal unit. Growth restriction successfully balances reduced oxygen delivery and consumption; however, chronic hypoxia is responsible for fetal blood flow redistribution to cardinal organs (brain, myocardium, and adrenal glands), the so-called brain-sparing effect. The neurotrophin family comprises four structurally related molecules: the nerve growth factor (NGF), the brain-derived neurotrophic factor (BDNF), the neurotrophin-3 (NT-3), and the neurotrophin-4 (NT-4). By exerting neuroprotection, neurotrophins are critical for pre- and postnatal brain development. Based on the assumption that the brain-sparing effect might be activated in fullterm IUGR infants, we hypothesized that circulating neurotrophin levels should not differ between IUGR and appropriate for gestational age (AGA) infants. Indeed, we found that in both groups, circulating NT-3, NT-4, and BDNF levels do not differ, and this finding could possibly be attributed to the activation of the brain-sparing effect. In contrast, NGF levels were higher in the AGA compared to the IUGR group. However, only NGF levels positively correlated with the customized centile and the birth weight of the infants, and both of them were lower in the IUGR group.