HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer
HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer
复制标题
DOI：
10.1080/2162402x.2015.1005507
复制
发表时间：
2015-05-01
期刊：
影响因子：
7.2
通讯作者：
Sato, Noriyuki
中科院分区：
文献类型：
--
作者：
Hirohashi, Yoshihiko;Torigoe, Toshihiko;Sato, Noriyuki
细胞毒性T淋巴细胞（CTL）识别人类白细胞抗原（HLA）I类和抗原肽复合物，在癌症免疫中起着至关重要的作用。我们最近的研究表明，HLA I类下调与预后不良有关，低水平的肿瘤内CTL与铂类耐药有关，表明免疫监视的重要性。
Cytotoxic T lymphocytes (CTLs) recognize the human leukocyte antigen (HLA) class I and antigenic peptide complex, and they play a crucial role in cancer immunity. Our recent study revealed that HLA class I downregulation is related to poorer prognosis and a low level of intratumoral CTLs is associated with platinum resistance, indicating the significance of immunological surveillance.