Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans.
Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans.
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DOI：
10.1523/jneurosci.4899-09.2010
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发表时间：
2010-05-19
期刊：
影响因子：
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通讯作者：
Meyer-Lindenberg A
中科院分区：
文献类型：
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作者：
Zink CF;Stein JL;Kempf L;Hakimi S;Meyer-Lindenberg A
神经肽，加压素，是哺乳动物社会行为和情绪的调节器，特别是恐惧、攻击性和焦虑。在人类中，后叶加压素的行为效应背后的神经回路尚不清楚。在处理健康男性志愿者面部情绪的过程中，使用40IU加压素或安慰剂的双盲交叉给药和功能磁共振成像，我们表明加压素特异性地减少了膝下扣带回皮质的差异激活。对先前评估的杏仁核、膝下扣带回和膝上扣带回之间的回路进行的结构方程模拟显示，在加压素作用下，膝下扣带回和膝上扣带回之间的有效连接发生了变化。我们的数据显示，加压素对与情绪调节有关的内侧前额叶皮质-杏仁体回路皮质部分的活动和连通性产生影响，为加压素对人类社会行为的影响提供了第一个神经基础的数据，对情绪和焦虑障碍具有潜在的治疗意义。
The neuropeptide, vasopressin, is a modulator of mammalian social behavior and emotion, particularly fear, aggression, and anxiety. In humans, the neural circuitry underlying behavioral effects of vasopressin is unknown. Using a double-blind crossover administration of 40 IU vasopressin or placebo and functional MRI during processing of facial emotions in healthy male volunteers, we show that vasopressin specifically reduces differential activation in the subgenual cingulate cortex. Structural equation modeling of a previously evaluated circuit between amygdala, subgenual cingulate, and supragenual cingulate revealed altered effective connectivity between subgenual and supragenual cingulate under vasopressin. Our data demonstrate an impact of vasopressin on activity and connectivity in the cortical component of a medial prefrontal cortex-amygdala circuit implicated in emotional regulation, providing the first data on the neural basis for the effects of vasopressin on social behavior in humans with potential therapeutic significance for mood and anxiety disorders.