The cannabis withdrawal syndrome
The cannabis withdrawal syndrome
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DOI：
10.1097/01.yco.0000218592.00689.e5
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发表时间：
2006-05-01
影响因子：
6.9
通讯作者：
Hughes, JR
中科院分区：
文献类型：
--
作者：
Budney, AJ;Hughes, JR
10.大麻依赖治疗的需求急剧增长。大多数接受治疗的人很难实现和保持对大麻的戒断。了解大麻戒断综合征对戒烟尝试的影响显然很重要。然而，大麻长期以来一直被认为是一种“软”毒品，许多人继续质疑一个人是否真的可以依赖大麻。怀疑主义通常集中在大麻使用是否会导致“生理”依赖或戒断，以及戒断是否具有临床重要性。最近的研究结果大麻戒断的神经生物学基础已经建立，通过发现内源性大麻素系统，大麻素受体的鉴定，和大麻素受体拮抗剂的沉淀戒断的演示。实验室研究已经建立了大麻戒断综合征的可靠性，有效性和时间过程，并开始探索各种药物对这种戒断的影响。临床样本的报告表明，该综合征是常见的治疗seekers.Summary一个临床上重要的戒断综合征与大麻依赖已经建立。更多的研究必须确定大麻戒断如何影响戒烟尝试以及治疗其症状的最佳方法。
Purpose of review The demand for treatment for cannabis dependence has grown dramatically. The majority of the people who enter the treatment have difficulty in achieving and maintaining abstinence from cannabis. Understanding the impact of cannabis withdrawal syndrome on quit attempts is of obvious importance. Cannabis, however, has long been considered a 'soft' drug, and many continue to question whether one can truly become dependent on cannabis. Skepticism is typically focused on whether cannabis use can result in 'physiological' dependence or withdrawal, and whether withdrawal is of clinical importance.Recent findings The neurobiological basis for cannabis withdrawal has been established via discovery of an endogenous cannabinoid system, identification of cannabinoid receptors, and demonstrations of precipitated withdrawal with cannabinoid receptor antagonists. Laboratory studies have established the reliability, validity, and time course of a cannabis withdrawal syndrome and have begun to explore the effect of various medications on such withdrawal. Reports from clinical samples indicate that the syndrome is common among treatment seekers.Summary A clinically important withdrawal syndrome associated with cannabis dependence has been established. Additional research must determine how cannabis withdrawal affects cessation attempts and the best way to treat its symptoms.