Physical activity and reduced risk of ovarian cancer
Physical activity and reduced risk of ovarian cancer
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DOI：
10.1016/s0029-7844(00)00972-8
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发表时间：
2000-10-01
影响因子：
7.2
通讯作者：
Kriska, AM
中科院分区：
文献类型：
--
作者：
Cottreau, CM;Ness, RB;Kriska, AM
目的：研究闲暇时间体力活动与卵巢癌之间的关系。方法：我们使用的数据来自一项基于人群的病例对照研究。病例（n = 767）为1994-1998年诊断为上皮性卵巢癌的20-69岁女性，居住在宾夕法尼亚州、新泽西或特拉华州的特定地区。对照组（n = 1367）通过随机数字拨号和卫生保健财务管理局文件进行了确定，并与年龄和居住县的病例进行了频率匹配。在面对面采访中获得了有关一生休闲时间身体活动的信息。结果：休闲时间身体活动与卵巢癌发生率的降低显着相关（P = 0.01）。在调整年龄、产次、口服避孕药使用、输卵管结扎、卵巢癌家族史、种族和体重指数后，活动水平最高的女性与活动水平最低的女性相比，卵巢癌的优势比为0.73（95%CI 0.56，0.94）。当按生活中的各个回忆时间段分析这种关系时，14-17岁、18-21岁、22-29岁、30-39岁、40-49岁和>50岁的最高与最低活动类别的比值比为0.64- 0.78。结论：闲暇时间体力活动与卵巢上皮癌的发生率降低有关。（《妇产科》2000年;96：609-14。(C)2000年由美国妇产科医师学会。
Objective: To examine the relation between leisure-time physical activity and ovarian cancer.Methods: We used data from a population based case-control study. Cases (n = 767) were women 20-69 years of age in whom epithelial ovarian cancer was diagnosed during 1994-1998 and who resided in a defined region of Pennsylvania, New Jersey, or Delaware. Controls (n = 1367) were ascertained by using random-digit dialing and Health Care Financing Administration files and were frequency-matched to cases for age and county of residence. Information on lifetime leisure-time physical activity was obtained during in-person interviews.Results: Leisure-time physical activity was significantly associated with reduced occurrence of ovarian cancer (P =.01). After adjustment for age, parity, oral contraceptive use, tubal ligation, family history of ovarian cancer, race, and body mass index, women with the highest level of activity had an odds ratio of 0.73 (95% CI 0.56, 0.94) for ovarian cancer compared with women with the lowest level of activity. When the relation was analyzed by Various recalled time periods during life, the odds ratios for the highest versus the lowest category of activity at ages 14-17, 18-21, 22-29, 30-39, 40-49, and >50 years ranged from 0.64-0.78.Conclusion: Leisure-time physical activity is associated with reduced occurrence of epithelial ovarian cancer. (Obstet Gynecol 2000;96:609-14. (C) 2000 by The American College of Obstetricians and Gynecologists.).