POISON INDUCED PICA IN RATS
POISON INDUCED PICA IN RATS
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DOI：
10.1016/0031-9384(76)90171-2
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发表时间：
1976-01-01
影响因子：
2.9
通讯作者：
MITCHELL, LK
中科院分区：
文献类型：
--
作者：
MITCHELL, D;WELLS, C;MITCHELL, LK
本文报告了两个研究中毒对非营养物质消耗影响的实验。在第一个实验中，大鼠被氯化锂或红鱿鱼中毒，并在食物和土壤之间进行选择。在第二个实验中，大鼠用环磷酰胺中毒，并在食物和高岭土之间进行选择。治疗后，两个实验中的中毒大鼠增加了非营养物质的消耗。用对数剂量中毒的大鼠消耗的非营养物质的量与所施用的毒药的量成比例。异食癖增加可能是大鼠的一种疾病反应行为，类似于其他物种的呕吐，可用作毒性药物作用的易于量化的行为测定。
Two experiments investigating the effects of poisoning on the consumption of non-nutritive substances are reported. In the 1st experiment, rats were poisoned with lithium chloride or Red Squill and offered a choice between food and soil. In the 2nd experiment, rats were poisoned with cyclophosphamide and offered a choice between food and kaolin. Following treatment, poisoned rats in both experiments increased their consumption of the non-nutritive substances. Rats poisoned with logarithmic doses consumed amounts of the non-nutritive substances proportionate to the amount of poison administered. Increased pica may be an illness-response behavior of the rat, analogous to vomiting in other species, which can be used as an easily quantifiable behavioral assay of noxious drug effects.