New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation
New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation
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DOI：
10.1039/c2cc16959b
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Hevia, Eva
中科院分区：
文献类型：
--
作者：
Baillie, Sharon E.;Blair, Victoria L.;Hevia, Eva
比较了相关的锌酸锂[(THF)LiZn(TMP)Bu-t(2)](1)和[(PMDETA)(LiZnBu3)-Bu-t](2)对吡嗪的反应性，揭示了这一敏感杂环的选择性2，5-双质子化和室温C-H烷基化的两种新的双金属方法。
Comparing the reactivity of the related lithium zincates [(THF)LiZn(TMP)Bu-t(2)] (1) and [(PMDETA)(LiZnBu3)-Bu-t] (2) towards pyrazine discloses two new bimetallic approaches for the selective 2,5-dideprotonation and room temperature C-H alkylation of this sensitive heterocycle.