Gold(I)-Catalyzed Tandem Cyclization Approach to Tetracyclic Indolines
Gold(I)-Catalyzed Tandem Cyclization Approach to Tetracyclic Indolines
复制标题
DOI：
10.1021/ol100153h
复制
发表时间：
2010-04-02
期刊：
影响因子：
5.2
通讯作者：
Wang, Xiang
中科院分区：
文献类型：
--
作者：
Liu, Yongxiang;Xu, Wenqing;Wang, Xiang
报道了两个高度立体选择性的阳离子金催化的烷基啉酮串联环化反应。这些反应展示了一种快速构建高功能化多环吲哚的新策略。该方法成功地合成了苦参生物碱。
Two highly stereoselective cationic gold(I)-catalyzed tandem cyclization reactions of alkynylindoles are described. These reactions demonstrated a novel and general strategy to rapidly construct highly functionalized polycyclic indolines. This approach was successfully employed for a formal synthesis of the akuammillne alkaloid minfiensine.