Comparison of Survival Outcomes Among Cancer Patients Treated In and Out of Clinical Trials
Comparison of Survival Outcomes Among Cancer Patients Treated In and Out of Clinical Trials
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DOI：
10.1093/jnci/dju002
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发表时间：
2014-03-01
影响因子：
10.3
通讯作者：
Hershman, Dawn L.
中科院分区：
文献类型：
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作者：
Unger, Joseph M.;Barlow, William E.;Hershman, Dawn L.
背景临床试验是在选定的患者群体中测试治疗的有效性。我们研究了癌症临床试验患者是否类似于非试验，“现实世界”的患者方面提出的特点和survival.Methods我们回顾了SWOG国家临床试验联盟数据库，以确定候选试验。将标准组患者的人口统计学因素、分期和总生存期与从监测、流行病学和最终结果项目中选择的非试验对照组进行比较。采用考克斯回归进行多变量生存分析。所有研究的总数据的生存函数分别按预后进行比较（>= 50% vs
Background Clinical trials test the efficacy of a treatment in a select patient population. We examined whether cancer clinical trial patients were similar to nontrial, "real-world" patients with respect to presenting characteristics and survival.Methods We reviewed the SWOG national clinical trials consortium database to identify candidate trials. Demographic factors, stage, and overall survival for patients in the standard arms were compared with nontrial control subjects selected from the Surveillance, Epidemiology, and EndResults program. Multivariable survival analyses using Cox regression were conducted. The survival functions from aggregate data across all studies were compared separately by prognosis (>= 50% vs