The Combination Effects of Resveratrol and Swimming HIIT Exercise on Novel Object Recognition and Open-field Tasks in Aged Rats
The Combination Effects of Resveratrol and Swimming HIIT Exercise on Novel Object Recognition and Open-field Tasks in Aged Rats
复制标题
DOI：
10.1080/0361073x.2020.1754015
复制
发表时间：
2020-04-25
影响因子：
1.8
通讯作者：
Esmaeilpour, Khadijeh
中科院分区：
文献类型：
--
作者：
Amirazodi, Fatemeh;Mehrabi, Amin;Esmaeilpour, Khadijeh
前言：白藜芦醇是一种天然多酚类化合物，广泛存在于葡萄和红酒中，具有多种贝内。对身体健康的影响。高强度间歇运动（HIIT）是一种间歇训练形式，可提高运动能力并对健康有保护作用。本研究旨在探讨游泳HIIT和补充白藜芦醇对老年大鼠在新物体识别和旷场实验中行为功能的交互作用。研究方法：将45只20月龄的老年雄性Wistar大鼠随机分为5组：对照组（C）、游泳HIIT组（SW-HIIT）、补充白藜芦醇的游泳HIIT组（SW-HIIT-R）、补充白藜芦醇组（R）和补充白藜芦醇的溶剂组（SR）。还有另一组包括幼龄动物（2月龄），用于与老龄动物进行比较。游泳HIIT和白藜芦醇补充组进行运动，并接受白藜芦醇（10 mg/kg/天，灌胃）6周。新的物体识别和旷场测试用于评估动物的行为功能。结果：HIIT和白藜芦醇对老年动物的再认记忆有显著的改善作用。此外，在旷场实验中，HIIT和白藜芦醇似乎可以部分调节老年动物的焦虑样行为。
Introduction: Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous bene?cial health effects in the body. High-Intensity Interval Exercise (HIIT) is a form of interval training that provides improved athletic capacity and has a protective effect on health. The purpose of this study was to investigate the interactive effects of swimming HIIT and Resveratrol supplementation on behavioral function in Novel object recognition and open-field tests in aged rats. Methods: A total of 45 aged male Wistar rats with an age of 20 months were randomly assigned into five groups of control (C), & xfeff;swimming HIIT (SW-HIIT), & xfeff;swimming HIIT with Resveratrol supplementation (SW-HIIT-R), Resveratrol supplementation (R), and solvent of Resveratrol supplementation (SR). There was also another group that included young animals (2-month-old) and was used to compare with older animals. Swimming HIIT and Resveratrol supplementation groups performed the exercise and received Resveratrol (10 mg/kg/day, gavage) for six weeks. Novel object recognition and & xfeff;open-field tests were used for evaluating the behavioral functions in animals. Results: The results showed that HIIT and Resveratrol significantly improved recognition memory compared to old animals. Moreover, it seems that HIIT and Resveratrol partly could modulate anxiety-like behaviors compared to old animals in the open-field test.