Studies on the Localization of Dyes and Foreign Proteins in Normal and Malignant Tissues
Studies on the Localization of Dyes and Foreign Proteins in Normal and Malignant Tissues
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正常和恶性组织中染料和外来蛋白质定位的研究
DOI：
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发表时间：
1939
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影响因子：
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通讯作者：
F. Duran
中科院分区：
文献类型：
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作者：
F. Duran
英国学派对癌症移植的早期研究揭示了宿主血管反应的极端重要性，这是移植成功的一个不可或缺的条件（1）。血管间质的快速生长，与癌组织本身的生长平行，可能是毛细血管功能改变的原因，并导致渗透性增加。静脉注射细菌毒素后，在移植和自发肿瘤中均出现了类似Shwartzman的现象，这一观察结果表明了这一点（2-5）。
长期以来，研究人员一直在寻找静脉注射后能定位于肿瘤的物质，希望能对肿瘤的生长产生一定的影响。染料似乎是最常用的。
克鲁克香克（Cruickshank）（6）已经回顾了关于这一主题的大量早期文献，除了对某些染料的观察外，这里不需要深入讨论。Weil（7）、Simpson和Marsh（8）观察到，少量注射的偶氮染料可使肿瘤坏死部分染色，但整个肿瘤直到注射足够的染料使许多正常组织变色后才开始着色。Ludford（9）表明，似乎定位于肿瘤中的台盼蓝不被癌细胞吸收，而是被基质和周围组织中的成纤维细胞、组织细胞、单核细胞和淋巴细胞吸收。目前的研究是从血管通透性在肿瘤材料定位中的可能作用的角度进行的。1
The early studies of the English school on cancer transplantation disclosed the paramount importance of the vascular reaction of the host as an indispensable condition for the success of the grafting (1). The rapid growth of the vascular stroma, paralleling the growth of the cancer tissue proper, may be responsible for functional alterations in the blood capillaries and account for an increased permeability. That such is the case is indicated by the observation that a Shwartzman-like phenomenon takes place in both transplanted and spontaneous tumors following the intravenous injection of bacterial toxins (2–5).
Investigators have long sought substances which would localize in tumors after intravenous injection, with the hope that some influence could be exerted on the growth. Dyestuffs seem to have been most generally used.
Cruickshank (6) has reviewed the extensive earlier literature on the subject, which need not be gone into here except for observations on certain dyes. It was observed by Weil (7) and Simpson and Marsh (8) that the azo-dyes, injected in small amounts, stained the necrotic parts of the tumor but the whole tumor did not take up the color until sufficient dye had been injected to discolor many of the normal tissues. Ludford (9) showed that trypan blue, which appeared to localize in the tumor, was not taken up by the cancer cells but by the fibroblasts, histiocytes, monocytes and lymphocytes present in the stroma and surrounding tissue. The present investigation has been undertaken from the point of view of the possible role of vessel permeability in the localization of materials in tumors.1