A systematic evaluation for the potential translation of CD166-related expression as a cancer biomarker
A systematic evaluation for the potential translation of CD166-related expression as a cancer biomarker
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CD166 相关表达作为癌症生物标志物的潜在转化的系统评估
DOI：
10.1080/14737159.2016.1211932
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发表时间：
2016-07
影响因子：
5.1
通讯作者：
Chen WT
中科院分区：
文献类型：
--
作者：
Xiao M;Chen WT
摘要引言：许多基础研究为CD166与肿瘤的相关性提供了证据。然而，随着对CD 166在肿瘤领域的临床应用价值的研究沿着增多，也出现了一些有争议和不确定的结果。涵盖领域：通过检索PubMed和EMBASE数据库，对已发表文章进行适当查询和收集。随后通过荟萃分析对CD166相关表达和癌症进行了系统和定量总结，以阐明其作为癌症生物标志物的潜在翻译的临床意义。专家评论：结果表明，总CD 166与肿瘤风险相关，膜CD 166与淋巴结转移相关，胞浆CD 166与TNM分期和无病生存相关。细胞膜CD 166、细胞质CD 166和可溶性CD 166显示出很大的潜力，可用作预测癌症总生存的一组标志物。我们可以得出结论，CD166作为癌症的风险因素发挥作用，并且观察到其不同功能亚型的改变与特定或相互作用的临床结果相关。
ABSTRACT Introduction: Many basic studies have provided some evidences for the correlations of CD166 to cancer. However, along with the growing studies on the clinical values of CD166 in cancer areas, some controversial and inconclusive results were obtained. Areas covered: An appropriate query and collection of the published articles was conducted through search in PubMed and EMBASE database. A subsequent systematical and quantitative summary of CD166 related expression and cancer was conducted with meta-analysis to clarify its clinical significance for potential translation as cancer biomarkers. Expert commentary: The overall results suggested total CD166 correlated to cancer risk, membrane CD166 correlated to nodal metastasis and cytoplasmic CD166 correlated to TNM stage, and disease-free survival. The membrane CD166, cytoplasmic CD166 and soluble CD166 showed great potential to be used as a panel of markers for predicting cancer overall survival. We might conclude that CD166 functions as a risk factor for cancers, and the alterations of its different functional isoforms were observed to correlate with specific or interplayed clinical outcomes.
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