Functional Significance of Mirna-149 in Lung Cancer: Can it be Utilized as a Potential Biomarker or a Therapeutic Target?
Functional Significance of Mirna-149 in Lung Cancer: Can it be Utilized as a Potential Biomarker or a Therapeutic Target?
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DOI：
10.26420/austinjmedoncol.2020.1048
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发表时间：
2020-06
期刊：
影响因子：
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通讯作者：
Chauhan Sj;Thyagarajan A;Sahu Rp
中科院分区：
文献类型：
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作者：
Chauhan Sj;Thyagarajan A;Sahu Rp
越来越多的证据证明了miR-149作为一种有前途的肿瘤抑制性非编码RNA的重要性，其在调节参与癌症生长和转移的基因中发挥关键作用。值得注意的是，miR-149在诊断/预后或治疗靶点中用作潜在生物标志物的能力也已经使用各种细胞和临床前模型以及在肺癌的临床环境中进行了探索。虽然miR-149在评估肿瘤进展方面的适用性已被提出，但其在预测治疗结果方面的潜力需要在肺癌患者的不同环境中进行验证。本文综述了miR-149在非小细胞肺癌中的功能意义以及目前面临的挑战。
Accumulating evidence has documented the significance of miR-149 as a promising tumor-suppressive non-coding RNA that play critical roles in regulating genes involved in cancer growth and metastasis. Notably, the ability of miR-149 to be utilized as a potential biomarker in the diagnosis/prognosis or a therapeutic target has also been explored using various cellular and preclinical models, as well as in clinical settings of lung cancer. While the applicability of miR-149 in assessing tumor progression has been suggested, its potential in predicting treatment outcomes is needed to be verified in diverse settings of lung cancer patients. The current review presents an overview of the functional significance of miR-149 with ongoing challenges in non-small cell lung cancer.