Impact of Human Papillomavirus on Oropharyngeal Cancer Biology and Response to Therapy Implications for Treatment
Impact of Human Papillomavirus on Oropharyngeal Cancer Biology and Response to Therapy Implications for Treatment
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DOI：
10.1016/j.otc.2013.04.009
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发表时间：
2013-08-01
影响因子：
1.7
通讯作者：
Rocco, James W.
中科院分区：
文献类型：
--
作者：
Bonilla-Velez, Juliana;Mroz, Edmund A.;Rocco, James W.
起源于人乳头状瘤病毒感染的口咽鳞状细胞癌（OPSCC）已成为头颈部癌症的一个新实体，定义了一个具有不同致癌作用、危险因素特征和临床表现的患者子集，这些患者的生存率明显高于经典OPSCC患者。正在积极研究治疗的降级和相关生物标志物的鉴定，以帮助患者选择。本文综述了这些研究结果在临床护理中的意义。
Oropharyngeal squamous cell carcinoma (OPSCC) originating from human papillomavirus infection has emerged as a new entity in head and neck cancer, defining a subset of patients with distinct carcinogenesis, risk factor profiles, and clinical presentation that show markedly improved survival than patients with classic OPSCC. De-escalation of therapy and identification of relevant biomarkers to aid in patient selection are actively being investigated. This review addresses the implications of these findings in clinical care.