Microbial Eukaryotes that Lack Sterols
Microbial Eukaryotes that Lack Sterols
复制标题
缺乏甾醇的微生物真核生物
DOI：
10.1111/jeu.12426
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发表时间：
2017
影响因子：
2.2
通讯作者：
Roger AJ
中科院分区：
文献类型：
--
作者：
Takishita K;Chikaraishi Y;Tanifuji G;Ohkouchi N;Hashimoto T;Fujikura K;Roger AJ
人们普遍认为，甾醇是真核生物细胞膜中关键的环三萜脂类，通过氧依赖的多酶途径合成。然而，也有已知的例外——纤毛原生动物，如asttrahymena，与各种低氧适应的真核生物一起产生，而不是固醇，环三萜脂质四羟醇，其生物合成不需要分子氧。在这里，我们报道了一些厌氧微生物真核生物（原生生物）既不利用固醇也不利用膜中的四羟丙醇。它们的膜中缺乏可检测的固醇样化合物，这可能为重新考虑真核生物中固醇和固醇样脂质的生理功能提供了机会。
It is widely held that sterols are key cyclic triterpenoid lipids in eukaryotic cell membranes and are synthesized through oxygen‐dependent multienzyme pathways. However, there are known exceptions―ciliated protozoans, such asTetrahymena, along with diverse low‐oxygen‐adapted eukaryotes produce, instead of sterols, the cyclic triterpenoid lipid tetrahymanol that does not require molecular oxygen for its biosynthesis. Here, we report that a number of anaerobic microbial eukaryotes (protists) utilize neither sterols nor tetrahymanol in their membranes. The lack of detectable sterol‐like compounds in their membranes may provide an opportunity to reconsider the physiological function of sterols and sterol‐like lipids in eukaryotes.