Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer: Quo vadis?
Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer: Quo vadis?
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DOI：
10.5306/wjco.v5.i2.71
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发表时间：
2014-05-10
影响因子：
2.8
通讯作者：
Dalamaga, Maria
中科院分区：
文献类型：
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作者：
Christodoulatos, Gerasimos Socrates;Dalamaga, Maria
乳腺癌（BC）是女性中最常见的非皮肤癌类型，也是西方国家癌症相关死亡的主要原因。发现对 BC 具有诊断、预后或预测用途以及治疗价值的新型生物标志物具有重要意义。 Micro-RNA (miRNA) 属于一类新型内源性干扰 RNA，通过 mRNA 靶向在转录后基因沉默中发挥关键作用，因此参与许多生物过程，包括细胞凋亡、细胞周期控制、细胞增殖、DNA 修复、免疫、代谢、应激、衰老等。miRNA 主要在肿瘤抑制或致癌方面发挥作用。 方式。利用高通量技术检测到的BC中miRNA的特定异常表达模式反映了它们在癌症发生、进展、迁移、侵袭和转移中的关键作用。检测 BC 患者血浆中的循环细胞外 miRNA 可能会提供有利于 BC 诊断和预后的新型非侵入性生物标志物，同时，越来越多的证据强调了 miRNA 作为有价值的生物标志物对预测化疗或放疗反应的可能贡献。 BC 的体外和体内研究数据揭示了通过 miRNA 递送和 miRNA 抑制实现的有前景的治疗方法。本综述的目的是探讨 miRNA 在 BC 发病机制中的本体论作用，并强调它们的潜力，不仅作为具有诊断和预后意义的非侵入性循环生物标志物，而且作为帮助 BC 管理的治疗反应预测因子和治疗靶点。 (C) 2014 百事登出版集团有限公司。版权所有。
Breast cancer (BC) is the most frequent type of non skin cancer among women and a major leading cause of cancer-related deaths in Western countries. It is substantial to discover novel biomarkers with diagnostic, prognostic or predictive usefulness as well as therapeutic value for BC. Micro-RNAs (miRNAs) belong to a novel class of endogenous interfering RNAs that play a crucial role in post transcriptional gene silencing through mRNA targeting and, thus, are involved in many biological processes encompassing apoptosis, cell-cycle control, cell proliferation, DNA repair, immunity, metabolism, stress, aging, etc. MiRNAs exert their action mainly in a tumor suppressive or oncogenic manner. The specific aberrant expression patterns of miRNAs in BC that are detected with the use of high-throughput technologies reflect their key role in cancer initiation, progression, migration, invasion and metastasis. The detection of circulating extracellular miRNAs in plasma of BC patients may provide novel, non-invasive biomarkers in favor of BC diagnosis and prognosis and, at the same time, accumulating evidence has underscored the possible contribution of miRNAs as valuable biomarkers to predict response to chemotherapy or radiotherapy. Data from in vitro and in vivo studies on BC have revealed promising therapeutic approaches via miRNA delivery and miRNA inhibition. The purpose of this review is to explore the ontological role of miRNAs in BC etiopathogenesis as well as to highlight their potential, not only as non-invasive circulating biomarkers with diagnostic and prognostic significance, but also as treatment response predictors and therapeutic targets aiding BC management. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.