Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis
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DOI：
10.1136/bmj.38731.532766.f6
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发表时间：
2006-02-18
影响因子：
105.7
通讯作者：
Baker, G
中科院分区：
文献类型：
--
作者：
Buscemi, N;Vandermeer, B;Baker, G
目的对外源性褪黑素治疗继发性睡眠障碍和伴随睡眠受限的睡眠障碍，如时差和轮班障碍的有效性和安全性进行系统的综述。资料来源13个电子数据库和相关综述和收录研究的参考目录；美国钢铁协会摘要(1999-2003)。研究选择疗效综述包括随机对照试验；模具安全性综述包括随机和非随机对照试验。质量评估随机对照试验采用Jadad量表和Schulz等人的标准，非随机对照试验采用Down和Black Checklist。数据提取和综合一位评价者和另一位评价者验证提取的数据。主要结果6项随机对照试验，97名参与者，没有证据表明褪黑素对继发性睡眠障碍患者的入睡潜伏期有影响(加权平均差-13.2(95%可信区间-27.3至0.9)分钟)。包括427名参与者的9项随机对照试验表明，没有证据表明褪黑素对伴有睡眠限制(-1.0、2.3至0.3分钟)的睡眠障碍患者的入睡潜伏期有影响。有651人参加的17项随机对照试验显示，短期(3个月或以下)服用褪黑素没有不良反应的证据。结论没有证据表明褪黑素对继发性钢结构障碍或伴随睡眠限制的睡眠障碍有效，如时差和轮班障碍。有证据表明，短期使用褪黑激素是安全的。
Objective To conduct a systematic review of the efficacy and safety of exogenous melatonin in managing secondary sleep disorders and sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder.Data sources 13 electronic databases and reference lists of relevant reviews and included Studies; Associated Professional Steel) Society abstracts (1999 to 2003).Study selection The efficacy review included randomised controlled trials; die safety review included randomised and non-randomised controlled trials.Quality assessment Randomised controlled trials were assessed by using the Jadad Scale and criteria by Schulz et al, and non-randomised controlled trials by the Downs and Black checklist.Data extraction and synthesis One reviewer extracted data and another reviewer verified the data extracted. The inverse variance method was Used to weight studies and the random effects model was used to analyse data.Main results Six randomised controlled trials with 97 participants showed no evidence that melatonin had an effect on sleep onset latency in people with secondary sleep disorders (weighted mean difference - 13.2 (95% confidence interval - 27.3 to 0.9) min). Nine randomised controlled trials with 427 participants showed no evidence that melatonin had an effect on sleep onset latency in people who had sleep disorders accompanying sleep restriction (- 1.0 2.3 to 0.3) min). 17 randomised controlled trials with 651 participants showed no evidence of adverse effects of melatonin with short term use (three months or less).Conclusions There is no evidence that melatonin is effective in treating secondary steel) disorders or sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. There is evidence that melatonin is safe with short term use.